Transcription Factor

Accessions: O60663 (JASPAR 2024)
Names: LIM homeobox transcription factor 1-beta, LIM/homeobox protein 1.2, LIM/homeobox protein LMX1B, LMX-1.2, LMX1B_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O60663
Length: 402
Pfam Domains: 56-111 LIM domain
115-172 LIM domain
220-276 Homeobox domain
244-272 Homeobox KN domain
Sequence:
(in bold interface residues)
1 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQ 60
61 RPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCME 120
121 KIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVS 180
181 PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV 240
241 SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSS 300
301 RMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGDHMNPYGNDSIFHDID 360
361 SDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS
Interface Residues: 220, 221, 222, 223, 261, 262, 264, 265, 268, 269, 272, 273, 276, 279, 280, 286, 289, 303
3D-footprint Homologues: 1puf_A, 6a8r_A, 3cmy_A, 2h1k_B, 1puf_B, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 2ld5_A, 7q3o_C, 6es3_K, 3a01_E, 2d5v_B, 7psx_B, 5hod_A, 1au7_A, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1b72_A, 4cyc_A, 2r5y_A, 5flv_I, 3l1p_A, 2hos_A, 1e3o_C, 1le8_A, 7xrc_C, 4qtr_D, 4xrm_B, 1o4x_A, 8g87_X, 1du0_A, 5zjt_E
Binding Motifs: MA0703.1 tyAATtAa
MA0703.2 awtTTAATTAa
MA0703.3 TTAATTAa
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]

Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.