Transcription Factor
| Accessions: | ZNF282 (SMILE-seq 1.0), Q9UDV7 (JASPAR 2024) |
| Names: | Fragment, Q05BY5_HUMAN, ZNF282, ZNF282 protein, HTLV-I U5RE-binding protein 1, HUB-1, Zinc finger protein 282, ZN282_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | SMILE-seq 1.0 1, JASPAR 2024 2 1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q05BY5 |
| Notes: | TF family: KRAB+C2H10 |
| Length: | 671 |
| Pfam Domains: | 93-170 Zinc finger protein 198-238 KRAB box 518-540 C2H2-type zinc finger 518-540 Zinc finger, C2H2 type 518-540 C2H2-type zinc finger 534-556 Zinc-finger double domain 545-569 C2H2-type zinc finger 546-568 Zinc finger, C2H2 type 561-584 Zinc-finger double domain 573-585 C2H2-type zinc finger 574-596 C2H2-type zinc finger 574-596 Zinc finger, C2H2 type 588-611 Zinc-finger double domain 602-624 C2H2-type zinc finger 602-622 C2H2-type zinc finger 602-624 Zinc finger, C2H2 type 616-640 Zinc-finger double domain 629-653 C2H2-type zinc finger 630-652 Zinc finger, C2H2 type 630-652 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MQFVSTRPQPQQLGIQGLGLDSGSWSWAQALPPEEVCHQEPALRGEMAEGMPPMQAQEWD 60 61 MDARRPMPFQFPPFPDRAPVFPDRMMREPQLPTAEISLWTVVAAIQAVERKVDAQASQLL 120 121 NLEGRTGTAEKKLADCEKTAVEFGNHMESKWAVLGTLLQEYGLLQRRLENLENLLRNRNF 180 181 WVLRLPPGSKGEAPKVPVTFVDIAVYFSEDEWKNLDEWQKELYNNLVKENYKTLMSLDAE 240 241 GSVPKPDAPVQAEPREEPCVWEQRHPEEREIPMDPEAGAEPLVPAQDASSQVKREDTLCV 300 301 RGQRGLEERAIPTESITDSPISAQDLLSRIKQEEHQCVWDQQDLADRDIPTDPNSESLIS 360 361 AHDILSWIKQEEQPYPWGPRDSMDGELGLDSGPSDSLLMVKNPPPAPPQPQPQPQPPQPQ 420 421 LQSQPQPQSLPPIAVAENPGGPPSRGLLDDGFQVLPGERGSGEAPPGGDRSTGGGGGDGG 480 481 GGGGGAEAGTGAGGGCGSCCPGGLRRSLLLHGARSKPYSCPECGKSFGVRKSLIIHHRSH 540 541 TKERPYECAECEKSFNCHSGLIRHQMTHRGERPYKCSECEKTYSRKEHLQNHQRLHTGER 600 601 PFQCALCGKSFIRKQNLLKHQRIHTGERPYTCGECGKSFRYKESLKDHLRVHSGGPGPGA 660 661 PRQLPPPPERD |
| Interface Residues: | 505, 507, 508, 511, 529, 530, 531, 532, 534, 535, 537, 538, 541, 546, 556, 557, 558, 559, 560, 562, 563, 566, 584, 585, 586, 587, 588, 591, 594, 595, 612, 613, 614, 615, 616, 617, 618, 619, 620, 623, 640, 641, 642, 643, 644, 645, 646, 647, 648, 650 |
| 3D-footprint Homologues: | 5v3j_F, 6u9q_A, 5yel_A, 6wmi_A, 5k5i_A, 7w1m_H, 5und_A, 5k5l_F, 1tf6_A, 2i13_A, 2jpa_A, 2kmk_A, 6blw_A, 5kkq_D, 5ei9_F, 8ssq_A, 8ssu_A, 6ml4_A, 7eyi_G, 6e94_A, 7ysf_A, 2lt7_A, 1ubd_C, 7n5w_A, 1tf3_A, 6jnm_A, 8cuc_F, 7y3l_A, 4x9j_A, 8gn3_A, 1llm_D, 1mey_C, 5kl3_A, 2drp_D, 1f2i_J, 2gli_A, 1g2f_F, 8h9h_G, 7y3m_I, 6a57_A, 3uk3_C, 2wbs_A, 7txc_E, 5yj3_D, 4m9v_C |
| Binding Motifs: | MA1154.1 cTTTCCCmyAACACkas ZNF282 GGKGyGGGAkg MA1154.2 cTTTCCCmyAACACk |
| Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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