Transcription Factor

						

			
Accessions: RFX1_MOUSE (HOCOMOCO 10), P48377 (JASPAR 2024)

			
Names: MHC class II regulatory factor RFX1, Regulatory factor X 1, RFX1_MOUSE, Transcription factor RFX1
Organisms: Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P48377
Length: 963
Pfam Domains:   209-367 RFX1 transcription activation region      
  419-488 RFX DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MATQSYVTELQAAPQASQPPQAPPQALPQPPPPAAPQPPAAATPQPQYVTELQSPQPQTQ   60
  61 PPGSQKQYVAELPAAPAPSQPATPAPSPVAQQYIVVTVSEGAMRASETVSEASPSSTASQ  120
 121 TGVPTQVVQQVQGTQQRLLVQASVQAKPGHVSPLQLTNIQVPQQAIPTQHLVVQSPAPGT  180
 181 KSGQVSLTVHSAQQVHSAPERSPVQANNSTSKTAGTPAATVQQLQVHSVQQSVPVTQERS  240
 241 VVQATPQTKAGPVQQLTVQGLQPVHVAQEVQQLPQVPVPHVYSSQVQYVEGGDASYTASA  300
 301 IRSSTYQYPETPIYTQTAGTSYYEASGTAAQVSTPATSQTVASSGSVPMYVSGSPIVASS  360
 361 SSSEAGASNSSVGAGGNGGGGSSGGGSGGSSGSGAGTYVIQGGYMLGNASQSYSHTTRAS  420
 421 PATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRR  480
 481 LGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGVANGVAV  540
 541 GQQSTGLSDISAQVQQYQQFLDASRSLPDFAELDLQGKVLPEGVGPGDIKAFQVLYREHC  600
 601 EAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPRASLVLLSKFQPV  660
 661 LQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRV  720
 721 KVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRC  780
 781 EDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSSGFPKAAKLFLLKWSFY  840
 841 SSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSL  900
 901 NPLDPDKDEEEEEEEESEDELPQDISLAAGSESPALGPEALEPPAKLARTDTRGLFVQAL  960
 961 PSS
Interface Residues: 463, 467, 480, 484, 489
3D-footprint Homologues: 1dp7_P
Binding Motifs: MA0509.1 GTygCCaTRGCAAC
RFX1_MOUSE.H10MO.C|M01322 sssscsGTTGCCAkGGcraCss
Binding Sites: MA0509.1.1
MA0509.1.10
MA0509.1.11
MA0509.1.12
MA0509.1.13
MA0509.1.14
MA0509.1.15
MA0509.1.16
MA0509.1.17
MA0509.1.18
MA0509.1.19
MA0509.1.2
MA0509.1.20
MA0509.1.3
MA0509.1.4
MA0509.1.5
MA0509.1.6
MA0509.1.7
MA0509.1.8
MA0509.1.9
			
Publications: Hsu Y.C, Liao W.C, Kao C.Y, Chiu I.M. Regulation of FGF1 gene promoter through transcription factor RFX1. The Journal of biological chemistry 285:13885-95 (2010). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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