Transcription Factor
| Accessions: | P55347 (JASPAR 2024) |
| Names: | Homeobox protein PKNOX1, Homeobox protein PREP-1, PBX/knotted homeobox 1, PKNX1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P55347 |
| Length: | 436 |
| Pfam Domains: | 277-316 Homeobox KN domain 278-316 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYR 60 61 HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK 120 121 AIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAI 180 181 TGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQ 240 241 LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN 300 301 LTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPS 360 361 ELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALA 420 421 PAHISGLVLENSDSLQ |
| Interface Residues: | 260, 262, 263, 265, 304, 305, 307, 308, 311, 312, 313, 315, 316 |
| 3D-footprint Homologues: | 1puf_A, 6fqp_B, 1puf_B, 4j19_B, 1mnm_C, 2ld5_A, 1le8_A, 1au7_A, 4xrs_G, 2lkx_A, 1le8_B, 6fqq_E, 2d5v_B, 1fjl_B, 4xrm_B, 7psx_B, 1k61_B |
| Binding Motifs: | MA0782.1 TGACAGsTGTCA MA0782.2 twTGAgTGACAGctr MA0782.3 TGAgTGACAG |
| Binding Sites: | MA0782.2.1 MA0782.2.10 MA0782.2.11 / MA0782.2.9 MA0782.2.11 / MA0782.2.12 MA0782.2.13 MA0782.2.14 MA0782.2.15 MA0782.2.13 / MA0782.2.16 MA0782.2.17 MA0782.2.14 / MA0782.2.18 MA0782.2.19 MA0782.2.1 / MA0782.2.2 MA0782.2.15 / MA0782.2.20 MA0782.2.2 / MA0782.2.3 MA0782.2.4 MA0782.2.5 / MA0782.2.6 MA0782.2.6 MA0782.2.7 MA0782.2.7 / MA0782.2.8 MA0782.2.9 MA0782.2.10 MA0782.2.12 MA0782.2.16 MA0782.2.17 MA0782.2.18 MA0782.2.19 MA0782.2.20 MA0782.2.3 MA0782.2.5 MA0782.2.8 MA0782.3.1 / MA0782.3.15 / MA0782.3.16 / MA0782.3.17 MA0782.3.10 MA0782.3.11 MA0782.3.12 MA0782.3.13 MA0782.3.14 MA0782.3.18 MA0782.3.19 MA0782.3.2 MA0782.3.20 MA0782.3.3 MA0782.3.4 MA0782.3.5 MA0782.3.6 MA0782.3.7 MA0782.3.8 MA0782.3.9 |
| Publications: | Modica L, Iotti G, D'Avola A, Blasi F. Prep1 (pKnox1) regulates mouse embryonic HSC cycling and self-renewal affecting the Stat1-Sca1 IFN-dependent pathway. PLoS One : (2014). [Pubmed] Penkov D, Mateos San Martín D, Fernandez-Díaz LC, Rosselló CA, Torroja C, Sánchez-Cabo F, Warnatz HJ, Sultan M, Yaspo ML, Gabrieli A, Tkachuk V, Brendolan A, Blasi F, Torres M. Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins. Cell Rep 3:1321-33 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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