Transcription Factor

						

			
Accessions: 5d39_A (3D-footprint 20231221)

			
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 488
Pfam Domains:    21-121 STAT protein, all-alpha domain
  123-365 STAT protein, DNA binding domain
  376-454 SH2 domain
Sequence: 
(in bold interface residues)		   1 QEELKFKTGLRRLQHRVGEIHLLREALALAMLLQETTGELEAAKALVLKRIQIWKRQQQL   60
  61 AGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVT  120
 121 SCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLPAKPPLVRADMVTEKQARELESTGEIIN  180
 181 NTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQ  240
 241 LQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAE  300
 301 VGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVL  360
 361 DLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDG  420
 421 SPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGVP  480
 481 ATIKMTVE
Interface Residues: 134, 215, 252, 253, 254, 255, 256
3D-footprint Homologues: 1bf5_A, 4y5w_B, 1bg1_A
Binding Motifs: 5d39_AC TTCCnGGAA
			
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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