Transcription Factor
| Accessions: | SP1_HUMAN (HOCOMOCO 10), P08047 (JASPAR 2024) |
| Names: | SP1_HUMAN |
| Organisms: | Homo sapiens, Rattus norvegicus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 785 |
| Pfam Domains: | 626-650 Zinc finger, C2H2 type 626-650 C2H2-type zinc finger 642-669 Zinc-finger double domain 656-680 Zinc finger, C2H2 type 658-680 C2H2-type zinc finger 673-695 Zinc-finger double domain 686-708 Zinc finger, C2H2 type 686-708 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSP 60 61 LALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTS 120 121 KEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQ 180 181 TVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQG 240 241 LANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVT 300 301 SGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVS 360 361 GLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPL 420 421 SGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQ 480 481 TITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTS 540 541 GIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTR 600 601 REACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTW 660 661 SYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALS 720 721 VGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINI 780 781 SGNGF |
| Interface Residues: | 610, 615, 616, 617, 618, 619, 621, 631, 633, 635, 638, 639, 640, 641, 642, 644, 645, 647, 648, 651, 668, 669, 670, 671, 672, 674, 675, 676, 679, 696, 697, 698, 699, 700, 701, 702, 703, 704, 707 |
| 3D-footprint Homologues: | 7ysf_A, 5yel_A, 2i13_A, 7eyi_G, 1ubd_C, 7n5w_A, 8h9h_G, 1tf3_A, 7y3l_A, 6ml4_A, 6jnm_A, 5und_A, 5k5i_A, 2kmk_A, 8ssu_A, 2gli_A, 8gn3_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 5kl3_A, 5ei9_F, 8ssq_A, 1mey_C, 5v3j_F, 2lt7_A, 7y3m_I, 6e94_A, 6wmi_A, 6a57_A, 2jpa_A, 7w1m_H, 3uk3_C, 8cuc_F, 2drp_D, 1f2i_J, 1llm_D, 7txc_E, 2wbs_A, 5yj3_D, 4m9v_C |
| Binding Motifs: | MA0079.2 CCCCkCCCCC MA0079.3 gCCCCkCCCCy MA0079.4 ywrRCCACGCCCmCh SP1_HUMAN.H10MO.C|M01523 gggrrgGGGGcGGGGcsrg MA0079.1 krGGsdkKGW MA0079.5 GGGGMGGrG |
| Binding Sites: | MA0079.1.5 MA0079.1.6 MA0079.1.7 MA0079.1.3 MA0079.1.2 MA0079.1.8 MA0079.1.4 MA0079.1.1 MA0079.2.1 MA0079.2.10 MA0079.2.11 MA0079.2.12 MA0079.2.13 MA0079.2.14 MA0079.2.15 MA0079.2.16 MA0079.2.17 MA0079.2.18 MA0079.2.19 MA0079.2.2 MA0079.2.20 MA0079.2.3 MA0079.2.4 MA0079.2.5 MA0079.2.6 MA0079.2.7 MA0079.2.8 MA0079.2.9 MA0079.3.1 MA0079.3.10 MA0079.3.11 MA0079.3.12 MA0079.3.13 MA0079.3.14 MA0079.3.15 MA0079.3.16 MA0079.3.17 MA0079.3.18 MA0079.3.19 MA0079.3.2 MA0079.3.20 MA0079.3.3 MA0079.3.4 MA0079.3.5 MA0079.3.6 MA0079.3.7 MA0079.3.8 MA0079.3.9 |
| Publications: | Thiesen H.-J., Bach C. Target detection assay (TDA): a versatile procedure to determine DNA binding sites as demonstrated on SP1 protein. Nucleic Acids Res. 18:3203-3209 (1990). [Pubmed] Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed] Raiber EA, Kranaster R, Lam E, Nikan M, Balasubramanian S. A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro. Nucleic Acids Res 40:1499-508 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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