Transcription Factor
| Accessions: | P50220 (JASPAR 2024) |
| Names: | Homeobox protein Nkx-2.1, NKX21_MOUSE, T/EBP, Thyroid nuclear factor 1, Thyroid transcription factor 1, Thyroid-specific enhancer-binding protein, TTF-1 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 372 |
| Pfam Domains: | 162-218 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGH 60 61 HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDP 120 121 RFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRF 180 181 KQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGG 240 241 GGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQSHAQQQAQQQAQAAQA 300 301 AAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAGLQGQVSSLSHLNSSGSDYGA 360 361 MSCSTLLYGRTW |
| Interface Residues: | 123, 124, 126, 127, 135, 139, 156, 161, 162, 163, 164, 165, 203, 204, 206, 207, 210, 211, 214, 215, 218, 228, 231 |
| 3D-footprint Homologues: | 3l1p_A, 1e3o_C, 6m3d_C, 4j19_B, 3a01_E, 1fjl_B, 6a8r_A, 3cmy_A, 1puf_A, 1ig7_A, 3d1n_M, 1mnm_C, 5zfz_A, 6fqp_B, 2h1k_B, 3lnq_A, 2lkx_A, 1zq3_P, 1jgg_B, 1nk2_P, 6es3_K, 2ld5_A, 7q3o_C, 2hdd_A, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 7psx_B, 4cyc_A, 5flv_I, 5zjt_E, 1au7_A, 5hod_A, 7xrc_C, 1le8_A, 2xsd_C, 1o4x_A, 4qtr_D, 8g87_X, 1du0_A, 1k61_B, 6fqq_E |
| Binding Motifs: | PH0171.1 yaAgCCACTTgAmhtt MA1994.1 rvCACTTGArmwh MA1994.2 CACTTGA |
| Binding Sites: | MA1994.2.6 MA1994.1.1 / MA1994.1.3 MA1994.1.10 / MA1994.1.15 MA1994.1.11 / MA1994.1.17 MA1994.1.12 / MA1994.1.18 MA1994.1.13 / MA1994.1.20 MA1994.1.14 MA1994.1.15 MA1994.1.16 MA1994.1.17 MA1994.1.18 MA1994.1.19 MA1994.1.2 / MA1994.1.4 MA1994.1.20 MA1994.1.3 MA1994.1.4 / MA1994.1.5 MA1994.1.5 / MA1994.1.6 MA1994.1.6 / MA1994.1.7 MA1994.1.7 / MA1994.1.8 MA1994.1.8 / MA1994.1.9 MA1994.1.10 / MA1994.1.9 MA1994.2.19 MA1994.1.1 MA1994.1.11 MA1994.1.12 MA1994.1.13 MA1994.1.14 MA1994.1.16 MA1994.1.19 MA1994.1.2 MA1994.2.1 / MA1994.2.10 / MA1994.2.11 / MA1994.2.12 / MA1994.2.13 / MA1994.2.16 / MA1994.2.17 / MA1994.2.2 / MA1994.2.20 / MA1994.2.7 / MA1994.2.8 / MA1994.2.9 MA1994.2.14 MA1994.2.15 MA1994.2.18 MA1994.2.3 MA1994.2.4 MA1994.2.5 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Clarke N, Biscocho J, Kwei KA, Davidson JM, Sridhar S, Gong X, Pollack JR. Integrative Genomics Implicates EGFR as a Downstream Mediator in NKX2-1 Amplified Non-Small Cell Lung Cancer. PLoS One : (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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