Transcription Factor
| Accessions: | STAT4_MOUSE (HOCOMOCO 10), P42228 (JASPAR 2024) |
| Names: | STAT4_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 749 |
| Pfam Domains: | 2-121 STAT protein, protein interaction domain 137-315 STAT protein, all-alpha domain 317-564 STAT protein, DNA binding domain 574-629 SH2 domain |
| Sequence: (in bold interface residues) | 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWEVASNNETMATILLQNL 60 61 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120 121 MPIQGPLEKSLQSSSVSERQRNVEHKVSAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180 181 MDQGDKNSILVNQEVLTLLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLLEELQDWK 240 241 KRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQLEKLQEQSTKMTYEGDPIPAQRAH 300 301 LLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKV 360 361 KASIDKNVSTLSNRRFVLCGTHVKAMSSEESSNGSLSVEFRHLQPKEMKCSTGSKGNEGC 420 421 HMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQN 480 481 LVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSEQLNMLAEKLTVQSNYNDGHLTWAKFC 540 541 KEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRF 600 601 SESHLGGITFTWVDQSENGEVRFHSVEPYNKGRLSALAFADILRDYKVIMAENIPENPLK 660 661 YLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPQSPSDLLP 720 721 MSPSAYAVLRENLSPTTIETAMNSPYSAE |
| Interface Residues: | 336, 418, 456, 457, 458, 459, 460 |
| 3D-footprint Homologues: | 1bf5_A, 4y5w_B, 1bg1_A |
| Binding Motifs: | MA0518.1 yTTCyrRGAArysr STAT4_MOUSE.H10MO.A|M01368 yTTCYyrGAAr MA0518.2 TTCyrRGAAr |
| Binding Sites: | MA0518.1.1 MA0518.1.10 MA0518.1.11 MA0518.1.12 MA0518.1.13 MA0518.1.14 MA0518.1.15 MA0518.1.16 MA0518.1.17 MA0518.1.18 MA0518.1.19 MA0518.1.2 MA0518.1.20 MA0518.1.3 MA0518.1.4 MA0518.1.5 MA0518.1.6 MA0518.1.7 MA0518.1.8 MA0518.1.9 MA0518.2.1 MA0518.2.10 MA0518.2.11 MA0518.2.12 MA0518.2.13 MA0518.2.14 MA0518.2.15 MA0518.2.16 MA0518.2.17 MA0518.2.18 MA0518.2.19 MA0518.2.2 MA0518.2.20 MA0518.2.3 MA0518.2.4 MA0518.2.5 MA0518.2.6 MA0518.2.7 MA0518.2.8 MA0518.2.9 |
| Publications: | Good S.R, Thieu V.T, Mathur A.N, Yu Q, Stritesky G.L, Yeh N, O'Malley J.T, Perumal N.B, Kaplan M.H. Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. Journal of immunology (Baltimore, Md. : 1950) 183:3839-47 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.