Transcription Factor

						

			
Accessions: EGR1 (SMILE-seq 1.0)

			
Names: Early growth response protein 1, EGR-1, EGR1, EGR1_MOUSE, Nerve growth factor-induced protein A, NGFI-A, Transcription factor Zif268, Zinc finger protein Krox-24
Organisms: Mus musculus
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: P08046
Length: 532
Pfam Domains:   132-217 Domain of unknown function (DUF3446)
  336-360 C2H2-type zinc finger
  336-360 Zinc finger, C2H2 type
  353-376 Zinc-finger double domain
  366-388 C2H2-type zinc finger
  366-388 Zinc finger, C2H2 type
  380-404 Zinc-finger double domain
  394-412 C2H2-type zinc finger
  394-416 Zinc finger, C2H2 type
  424-520 Domain of unknown function (DUF3432)
Sequence: 
(in bold interface residues)		   1 MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGG   60
  61 NSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKAMVETSYPS  120
 121 QTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSS  180
 181 SASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPA  240
 241 TKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQ  300
 301 DLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRHFSRSDELTRHIRIH  360
 361 TGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQK  420
 421 DKKADKSVVASPAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGF  480
 481 PSPSVATTFASVPPAFPTQVSSFPSAGVSSSFSTSTGLSDMTATFSPRTIEI
Interface Residues: 318, 322, 325, 336, 348, 349, 350, 351, 352, 354, 355, 374, 376, 377, 378, 379, 380, 381, 382, 383, 384, 404, 405, 406, 407, 408, 409, 410, 411, 412, 415
3D-footprint Homologues: 5kkq_D, 8ssq_A, 7w1m_H, 8ssu_A, 7ysf_A, 5ei9_F, 2kmk_A, 6jnm_A, 1tf3_A, 7n5w_A, 1tf6_A, 6u9q_A, 5yel_A, 4x9j_A, 2i13_A, 5kl3_A, 1ubd_C, 6wmi_A, 2jpa_A, 1mey_C, 5und_A, 1f2i_J, 5k5i_A, 6ml4_A, 2gli_A, 1g2f_F, 6blw_A, 8h9h_G, 7eyi_G, 5v3j_F, 2lt7_A, 6e94_A, 6a57_A, 2drp_D, 3uk3_C, 8cuc_F, 7y3l_A, 1llm_D, 7txc_E, 2wbs_A, 4m9v_C, 7y3m_I, 8gn3_A, 5yj3_D
Binding Motifs: EGR1 tGCGkGGGCGkrg
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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