Transcription Factor

						

			
Accessions: PO2F1_HUMAN (HOCOMOCO 10), P14859 (JASPAR 2024)

			
Names: NF-A1, Oct-1, Octamer-binding protein 1, Octamer-binding transcription factor 1, OTF-1, PO2F1_HUMAN, POU domain, class 2, transcription factor 1
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P14859
Length: 743
Pfam Domains:   281-354 Pou domain - N-terminal to homeobox domain
  380-436 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS   60
  61 LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ  120
 121 LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ  180
 181 QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQ  240
 241 PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI  300
 301 KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDS  360
 361 SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK  420
 421 EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP  480
 481 VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA  540
 541 SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP  600
 601 SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV  660
 661 FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ  720
 721 NSLFTVASASGAASTTTTASKAQ
Interface Residues: 306, 322, 323, 324, 325, 327, 328, 334, 338, 379, 380, 381, 382, 383, 384, 421, 422, 424, 425, 428, 429, 432, 433, 436
3D-footprint Homologues: 3l1p_A, 7u0g_M, 3d1n_M, 2xsd_C, 1o4x_A, 1e3o_C, 7xrc_C, 1au7_A, 8g87_X, 4j19_B, 3a01_E, 1ig7_A, 2h1k_B, 3cmy_A, 5jlw_D, 1puf_A, 1fjl_B, 5zjt_E, 4cyc_A, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 7q3o_C, 2ld5_A, 1nk2_P, 6es3_K, 5hod_A, 2hdd_A, 3rkq_B, 2r5y_A, 7psx_B, 2hos_A, 1b72_A, 1le8_A, 5flv_I, 1du0_A, 4qtr_D, 1k61_B, 4xrs_G
Binding Motifs: MA0785.1 awTATGcwAATt
PO2F1_HUMAN.H10MO.B|M01443 wATGcAAAt
MA0785.2 TATGcwAAT
			
Publications: Verrijzer C. P., Alkema M. J., van Weperen W. W., van Leeuwen H. C., Strating M. J. J., van der Vliet P. C. The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J. 11:4993-5003 (1992). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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