Transcription Factor

Accessions: O43889 (JASPAR 2024)
Names: cAMP-responsive element-binding protein 3, CREB-3, CREB3_HUMAN, Cyclic AMP-responsive element-binding protein 3, Leucine zipper protein, Luman, N-terminal Luman, Transcription factor LZIP-alpha, Transcriptionally active form
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O43889
Length: 395
Pfam Domains: 174-233 bZIP transcription factor
176-225 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSP 60
61 PASLNILSSSNPCLVHHDHTYSLPRETVSMDLGECEISLTGRTGFMGLAIHTFPFAESES 120
121 CRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRR 180
181 KIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAM 240
241 VIEISNKTSSSSTCILVLLVSFCLLLVPAMYSSDTRGSLPAEHGVLSRQLRALPSEDPYQ 300
301 LELPALQSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFSEP 360
361 LCRGPILPLQANLTRKGGWLPTGSPSVILQDRYSG
Interface Residues: 181, 184, 185, 187, 188, 191, 192
3D-footprint Homologues: 6mg1_B, 1dh3_C, 5t01_B, 5vpe_D
Binding Motifs: MA0638.1 rtGmCACGTCAycr
MA0638.2 tGmCACGTCAyc
Publications: DenBoer LM, Hardy-Smith PW, Hogan MR, Cockram GP, Audas TE, Lu R. Luman is capable of binding and activating transcription from the unfolded protein response element. Biochem Biophys Res Commun 331:113-9 (2005). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.