Transcription Factor
Accessions: | O43889 (JASPAR 2024) |
Names: | cAMP-responsive element-binding protein 3, CREB-3, CREB3_HUMAN, Cyclic AMP-responsive element-binding protein 3, Leucine zipper protein, Luman, N-terminal Luman, Transcription factor LZIP-alpha, Transcriptionally active form |
Organisms: | Homo sapiens |
Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | O43889 |
Length: | 395 |
Pfam Domains: | 174-233 bZIP transcription factor 176-225 Basic region leucine zipper |
Sequence: (in bold interface residues) | 1 MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSP 60 61 PASLNILSSSNPCLVHHDHTYSLPRETVSMDLGECEISLTGRTGFMGLAIHTFPFAESES 120 121 CRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRR 180 181 KIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAM 240 241 VIEISNKTSSSSTCILVLLVSFCLLLVPAMYSSDTRGSLPAEHGVLSRQLRALPSEDPYQ 300 301 LELPALQSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFSEP 360 361 LCRGPILPLQANLTRKGGWLPTGSPSVILQDRYSG |
Interface Residues: | 181, 184, 185, 187, 188, 191, 192 |
3D-footprint Homologues: | 6mg1_B, 1dh3_C, 5t01_B, 5vpe_D |
Binding Motifs: | MA0638.1 rtGmCACGTCAycr MA0638.2 tGmCACGTCAyc |
Publications: | DenBoer LM, Hardy-Smith PW, Hogan MR, Cockram GP, Audas TE, Lu R. Luman is capable of binding and activating transcription from the unfolded protein response element. Biochem Biophys Res Commun 331:113-9 (2005). [Pubmed] |
Related annotations: | PaperBLAST |
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