Transcription Factor
| Accessions: | Su(H) (DrosophilaTF 1.1), P28159 (JASPAR 2024) |
| Names: | J kappa-recombination signal-binding protein, RBP-J kappa, SUH_DROME, Suppressor of hairless protein |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 594 |
| Pfam Domains: | 122-252 LAG1, DNA binding 253-402 Beta-trefoil DNA-binding domain 439-518 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 MKSYSQFNLNAAAPPAIAYETTVVNPNGSPLDPHQQQQQQSQDMPHFGLPGPQPPSSQQQ 60 61 QQQLQVHHQQQQQQQQQQQQQQHQQQMQMSLLPGPYRPHIEEKKLTRDAMEKYMRERNDM 120 121 VIVILHAKVAQKSYGNEKRFFCPPPCIYLFGSGWRRRYEEMLQQGEGEQGAQLCAFIGIG 180 181 SSDQDMQQLDLNGKQYCAAKTLFISDSDKRKHFMLSVKMFYGNGHDIGVFNSKRIKVISK 240 241 PSKKKQSLKNADLCIASGTNVALFNRLRSQTVSTRYLHVENGHFHASSTQWGAFTIHLLD 300 301 DNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQMALLEADDPVSQLHKC 360 361 AFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMINDGACWTIISTDKAEYQFYEGMGP 420 421 VASPVTPVPIVNSLNLNGGGDVAMLELSGDNFTPHLQVWFGDVEAETMYRCTETLLCVVP 480 481 EISQFRGEWLWVRQPTQVPISLVRNDGIIYATGLTFTYTPEPGPRPHCNTQAEDVMRARQ 540 541 NNNNNNITSISNNNNSNNAGSPAAGGGLQQQQQQHQALPSISEVQWNSHGSGLS |
| Interface Residues: | 134, 137, 139, 239, 240, 243, 268, 269, 270 |
| 3D-footprint Homologues: | 3iag_C, 5e24_E, 3brd_A |
| Binding Motifs: | Su(H) rTGrGAr MA0085.1 byGTGRGAAmCkarmt |
| Binding Sites: | MA0085.1.1 MA0085.1.10 MA0085.1.2 MA0085.1.3 MA0085.1.4 MA0085.1.5 MA0085.1.6 MA0085.1.7 MA0085.1.8 MA0085.1.9 |
| Publications: | Nellesen D.T, Lai E.C, Posakony J.W. Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Developmental biology 213:33-53 (1999). [Pubmed] Bailey A. M., Posakony J. W. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to notch receptor activity. Genes Dev. 9:2609-2622 (1995). [Pubmed] |
| Related annotations: | PaperBLAST |
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