Transcription Factor

						

			
Accessions: 4roc_B (3D-footprint 20231221), 5n9g_B (3D-footprint 20231221), 5n9g_G (3D-footprint 20231221)

			
Names: TATA sequence-binding protein, TATA-binding factor, TATA-box factor, TATA-box-binding protein, TBP_HUMAN, Transcription initiation factor TFIID TBP subunit
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P20226
Length: 178
Pfam Domains:      7-89 Transcription factor TFIID (or TATA-binding protein, TBP)
   95-177 Transcription factor TFIID (or TATA-binding protein, TBP)
Sequence: 
(in bold interface residues)		   1 GPSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSS   60
  61 GKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLT  120
 121 HQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKG
Interface Residues: 11, 13, 41, 42, 56, 58, 64, 66, 100, 101, 103, 132, 133, 147, 149, 155, 157
3D-footprint Homologues: 6cnb_R, 1cdw_A, 5iy6_P, 7z7n_D, 1qna_B, 5n9g_G, 1ytb_A, 5oqj_O, 1ais_A, 4wzs_D
Binding Motifs: 4roc_AB GGnnTTAAAATAnGT
4roc_B TTAAAATA
5n9g_ABC gnnnnannTATTTTAAnnC
5n9g_FGH gnnTTAAAATAnnt
Binding Sites: 4roc_N
4roc_T
5n9g_D / 5n9g_I
5n9g_E / 5n9g_J
5n9g_a
5n9g_b
			
Publications: Gouge J, Satia K, Guthertz N, Widya M, Thompson AJ, Cousin P, Dergai O, Hernandez N, Vannini A. Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell 163:1375-87 (2015). [Pubmed]


Gouge J, Guthertz N, Kramm K, Dergai O, Abascal-Palacios G, Satia K, Cousin P, Hernandez N, Grohmann D, Vannini A. Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation. Nat Commun 8:130 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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