Transcription Factor

Accessions: 5d39_B (3D-footprint 20231221)
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 483
Pfam Domains: 16-119 STAT protein, all-alpha domain
121-360 STAT protein, DNA binding domain
371-449 SH2 domain
Sequence:
(in bold interface residues)
1 QEELKFKTGLRRLQHRVGEIHLLREALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAG 60
61 NGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSC 120
121 FLVEKQPPQVLKTQTKFQAGVRFLLGLRFPAKPPLVRADMVTEKQARELESTGEIINNTV 180
181 PLENSIPGNCCSALFKNLLLKKIKRCEGTESVTEEKCAVLFSASFTLGPGKLPIQLQALS 240
241 LPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNR 300
301 GLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKR 360
361 CLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIE 420
421 NIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGVPATIKM 480
481 TVE
Interface Residues: 132, 207, 247, 248, 249, 250, 251
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 5d39_BD TtcCtGgaa
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

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