Transcription Factor
| Accessions: | GLI2_HUMAN (HOCOMOCO 10), P10070 (JASPAR 2024) |
| Names: | GLI family zinc finger protein 2, GLI2_HUMAN, Tax helper protein, Zinc finger protein GLI2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P10070 |
| Length: | 1587 |
| Pfam Domains: | 470-497 Zinc finger, C2H2 type 490-515 Zinc-finger double domain 503-527 C2H2-type zinc finger 503-527 Zinc finger, C2H2 type 519-546 Zinc-finger double domain 533-558 C2H2-type zinc finger 533-558 Zinc finger, C2H2 type 564-589 Zinc finger, C2H2 type 564-589 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHA 60 61 PLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHP 120 121 YVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQM 180 181 TLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSD 240 241 ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL 300 301 SQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQSSES 360 361 AVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKED 420 421 LDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTRE 480 481 QKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGC 540 541 NKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQR 600 601 NDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGA 660 661 QSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLR 720 721 KHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPA 780 781 GLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASP 840 841 LGAGRPHNASSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGGP 900 901 PPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHE 960 961 APGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTD GGL 1020 1021 ARGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALD 1080 1081 EGTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNK 1140 1141 NNMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLD 1200 1201 STQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTI 1260 1261 SGALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQ 1320 1321 SYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSP 1380 1381 TGRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGA 1440 1441 PDHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSST 1500 1501 VDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAG 1560 1561 ISNMAVGDMSSMLTSLAEESKFLNMMT |
| Interface Residues: | 449, 450, 452, 453, 456, 485, 486, 487, 488, 489, 491, 492, 494, 495, 498, 515, 516, 517, 518, 519, 521, 522, 545, 546, 547, 548, 549, 550, 551, 552, 553, 556, 576, 577, 578, 579, 580, 581, 582, 583, 584, 587, 597, 598, 599, 600, 603, 606 |
| 3D-footprint Homologues: | 7w1m_H, 6wmi_A, 1ubd_C, 6jnm_A, 3uk3_C, 8cuc_F, 7y3l_A, 7n5w_A, 6blw_A, 1tf6_A, 5ei9_F, 5v3j_F, 2gli_A, 8h9h_G, 7eyi_G, 2i13_A, 6e94_A, 5k5i_A, 6a57_A, 2jpa_A, 5kkq_D, 8ssq_A, 8ssu_A, 1tf3_A, 6u9q_A, 4x9j_A, 1llm_D, 7txc_E, 5kl3_A, 7ysf_A, 5yj3_D, 1mey_C, 5und_A, 1f2i_J, 2kmk_A, 6ml4_A, 8gn3_A, 1g2f_F, 2lt7_A, 7y3m_I, 5yel_A, 2wbs_A, 2drp_D, 4m9v_C |
| Binding Motifs: | MA0734.1 gCGACCACmCwr MA0734.2 vGACCACCCACgwyG GLI2_HUMAN.H10MO.B|M01189 gTGGGTGGTCy |
| Publications: | Kinzler K. W., Vogelstein B. The GLI Gene Encodes a Nuclear Protein Which Binds Specific Sequences in the Human Genome. Mol. Cell. Biol. 10:634-642 (1990). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.