Transcription Factor
| Accessions: | CTCF_HUMAN (HOCOMOCO 10), CTCF (humanC2H2ZF-ChIP Feb2015), P49711 (JASPAR 2024) |
| Names: | 11-zinc finger protein, CCCTC-binding factor, CTCF_HUMAN, CTCFL paralog, Transcriptional repressor CTCF, CTCF, ENSG00000102974, P49711 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, humanC2H2ZF-ChIP Feb2015 2, JASPAR 2024 3 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: C2H2 experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 727 |
| Pfam Domains: | 266-288 C2H2-type zinc finger 266-288 Zinc finger, C2H2 type 280-305 Zinc-finger double domain 294-316 C2H2-type zinc finger 294-316 Zinc finger, C2H2 type 309-333 Zinc-finger double domain 322-345 C2H2-type zinc finger 322-345 Zinc finger, C2H2 type 337-360 Zinc-finger double domain 366-387 Zinc-finger double domain 379-401 Zinc finger, C2H2 type 379-401 C2H2-type zinc finger 394-417 Zinc-finger double domain 407-430 C2H2-type zinc finger 437-460 C2H2-type zinc finger 437-460 Zinc finger, C2H2 type 468-489 C2H2-type zinc finger 482-504 Zinc-finger double domain 512-533 Zinc-finger double domain 523-546 C2H2-type zinc finger 538-566 Zinc-finger double domain 555-576 Zinc finger, C2H2 type 555-577 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MEGDAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQTDGGEVVQDVNSSVQM 60 61 VMMEQLDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPV 120 121 PVTVPVATTSVEELQGAYENEVSKEGLAESEPMICHTLPLPEGFQVVKVGANGEVETLEQ 180 181 GELPPQEDPSWQKDPDYQPPAKKTKKTKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSEV 240 241 NAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCG 300 301 RAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYAS 360 361 VEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSG 420 421 TMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERY 480 481 ALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDM 540 541 HFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADNCAGPDGVEGENGGETKKSKRGRKR 600 601 KMRSKKEDSSDSENAEPDLDDNEDEEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRTN 660 661 QPKQNQPTAIIQVEDQNTGAIENIIVEVKKEPDAEPAEGEEEEAQPAATDAPNGDLTPEM 720 721 ILSMMDR |
| Interface Residues: | 266, 276, 277, 278, 279, 280, 283, 304, 305, 306, 307, 308, 311, 332, 333, 334, 335, 336, 338, 339, 341, 342, 343, 346, 362, 363, 364, 365, 367, 368, 369, 386, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 417, 418, 419, 420, 421, 423, 424, 425, 428, 447, 448, 449, 450, 451, 454, 457, 477, 478, 480, 481, 484, 490, 504, 505, 506, 507, 508, 509, 512, 516, 533, 534, 535, 536, 537, 538, 540, 544, 565, 566, 568, 569, 572 |
| 3D-footprint Homologues: | 2kmk_A, 7y3l_A, 2i13_A, 1mey_C, 7w1m_H, 2gli_A, 6wmi_A, 6jnm_A, 6a57_A, 6e94_A, 1ubd_C, 7n5w_A, 8ssu_A, 5kkq_D, 5ei9_F, 5yj3_D, 8ssq_A, 8h9h_G, 7eyi_G, 7ysf_A, 2jpa_A, 6ml4_A, 5v3j_F, 4x9j_A, 6blw_A, 6u9q_A, 7txc_E, 5kl3_A, 1f2i_J, 5und_A, 1g2f_F, 4m9v_C, 2lt7_A, 3uk3_C, 8cuc_F, 8gn3_A, 1llm_D, 2wbs_A, 5k5i_A, 7y3m_I, 2drp_D, 5yel_A, 5k5l_F, 1tf3_A, 1tf6_A |
| Binding Motifs: | MA0139.1 ygrCCAsyAGrkGGCrsyr CTCF_HUMAN.H10MO.A|M01070 ygrCCAsyAGrkGGCrsyrk CTCF_ChIP GCGCCCYCTGs MA1929.1 cTGCagTkcchscwgyggCCasyAGrkGGCrsyv MA1930.1 cTGCAgTkccmscwycyggCCAsyAGrkGGCrsyr MA0139.2 rCCAsyAGrkGGCrs MA1929.2 cTGCagTkcchscwgyggCCasyAGrkGGCr MA1930.2 cTGCAgTkccmscwycyggCCAsyAGrkGGCrs |
| Binding Sites: | MA0139.1.1 / MA0139.1.2 MA0139.1.10 MA0139.1.11 MA0139.1.12 MA0139.1.13 MA0139.1.14 MA0139.1.15 MA0139.1.16 MA0139.1.17 MA0139.1.18 MA0139.1.19 MA0139.1.20 MA0139.1.3 MA0139.1.4 MA0139.1.5 MA0139.1.6 MA0139.1.7 MA0139.1.8 MA0139.1.9 MA1929.1.1 MA1929.1.10 MA1929.1.11 MA1929.1.12 MA1929.1.13 MA1929.1.14 MA1929.1.15 MA1929.1.16 MA1929.1.17 MA1929.1.18 MA1929.1.19 MA1929.1.2 MA1929.1.20 MA1929.1.3 MA1929.1.4 MA1929.1.5 MA1929.1.6 MA1929.1.7 MA1929.1.8 MA1929.1.9 MA1930.1.1 MA1930.1.10 MA1930.1.11 MA1930.1.12 MA1930.1.13 MA1930.1.14 MA1930.1.15 MA1930.1.16 MA1930.1.17 MA1930.1.18 MA1930.1.19 MA1930.1.2 MA1930.1.20 MA1930.1.3 MA1930.1.4 MA1930.1.5 MA1930.1.6 MA1930.1.7 MA1930.1.8 MA1930.1.9 MA1929.2.1 MA1929.2.10 MA1929.2.11 MA1929.2.12 MA1929.2.13 MA1929.2.14 MA1929.2.15 MA1929.2.16 MA1929.2.17 MA1929.2.18 MA1929.2.19 MA1929.2.2 MA1929.2.20 MA1929.2.3 MA1929.2.4 MA1929.2.5 MA1929.2.6 MA1929.2.7 MA1929.2.8 MA1929.2.9 MA1930.2.1 MA1930.2.10 MA1930.2.11 / MA1930.2.15 MA1930.2.12 MA1930.2.13 MA1930.2.14 MA1930.2.16 MA1930.2.17 MA1930.2.18 MA1930.2.19 MA1930.2.2 MA1930.2.20 MA1930.2.3 MA1930.2.4 MA1930.2.5 MA1930.2.6 MA1930.2.7 MA1930.2.8 MA1930.2.9 |
| Publications: | Barski A, Cuddapah S, Cui K, Roh T.Y, Schones D.E, Wang Z, Wei G, Chepelev I, Zhao K. High-resolution profiling of histone methylations in the human genome. Cell 129:823-37 (2007). [Pubmed] Soochit W, Sleutels F, Stik G, Bartkuhn M, Basu S, Hernandez SC, Merzouk S, Vidal E, Boers R, Boers J, van der Reijden M, Geverts B, van Cappellen WA, van den Hout M, Ozgur Z, van IJcken WFJ, Gribnau J, Renkawitz R, Graf T, Houtsmuller A, Grosveld F, Stadhouders R, Galjart N. CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells. Nat Cell Biol 23:881-893 (2021). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.