Transcription Factor

						

			
Accessions: 6b0o_A (3D-footprint 20231221), 6b0q_A (3D-footprint 20231221)

			
Names: Wilms tumor protein, WT1_HUMAN, WT33
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 119
Pfam Domains:      7-29 C2H2-type zinc finger
    21-48 Zinc-finger double domain
    35-59 Zinc finger, C2H2 type
    35-59 C2H2-type zinc finger
    52-76 Zinc-finger double domain
    65-87 Zinc finger, C2H2 type
    65-87 C2H2-type zinc finger
    65-85 Zinc-finger of C2H2 type
   79-105 Zinc-finger double domain
   93-117 Zinc finger, C2H2 type
   93-115 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 HMRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHT   60
  61 GVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR
Interface Residues: 17, 18, 19, 20, 21, 23, 24, 26, 27, 30, 47, 48, 49, 50, 51, 53, 54, 58, 75, 76, 77, 78, 79, 80, 81, 82, 83, 105, 106, 107, 108, 109, 110, 111, 112, 113
3D-footprint Homologues: 6jnm_A, 3uk3_C, 7n5w_A, 2i13_A, 5ei9_F, 8ssq_A, 7w1m_H, 5und_A, 2kmk_A, 8ssu_A, 6ml4_A, 5v3j_F, 6blw_A, 5kkq_D, 6u9q_A, 8h9h_G, 7eyi_G, 2gli_A, 6e94_A, 7ysf_A, 6wmi_A, 2lt7_A, 1tf6_A, 7y3m_I, 2jpa_A, 1ubd_C, 8cuc_F, 1tf3_A, 7y3l_A, 7txc_E, 5kl3_A, 2wbs_A, 1mey_C, 2drp_D, 1f2i_J, 5k5i_A, 1g2f_F, 5yel_A, 4x9j_A, 6a57_A, 8gn3_A, 1llm_D, 5yj3_D, 4m9v_C
Binding Motifs: 6b0o_A GCGTGGGAGTGt
6b0q_A GCGTGGGaGt
Binding Sites: 6b0o_B
6b0o_C
6b0q_B
6b0q_C
			
Publications: Wang D, Horton JR, Zheng Y, Blumenthal RM, Zhang X, Cheng X. Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. Nucleic Acids Res 46:3864-3877 (2018). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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