Transcription Factor
| Accessions: | IRF2 (HT-SELEX2 May2017), IRF2_HUMAN (HOCOMOCO 10), P14316 (JASPAR 2024) |
| Names: | ENSG00000168310, IRF2, Interferon regulatory factor 2, IRF-2, IRF2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P14316 |
| Notes: | TF family: IRF experiment: HT-SELEX Hamming distance: 2 cycle: 3, TF family: IRF experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 3 |
| Length: | 349 |
| Pfam Domains: | 5-113 Interferon regulatory factor transcription factor |
| Sequence: (in bold interface residues) | 1 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAI 60 61 HTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSK 120 121 KGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVVGQ 180 181 SHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTDSVP 240 241 SDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIKEESNPVP 300 301 YNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC |
| Interface Residues: | 40, 42, 75, 79, 80, 82, 83, 86, 87 |
| 3D-footprint Homologues: | 2pi0_B, 1if1_B, 2o61_A, 2irf_L, 7oot_B |
| Binding Motifs: | IRF2_2 cGAAAsyGAAAs IRF2_methyl_1 yGAAAsyGAAAs IRF2_HUMAN.H10MO.C|M01267 sGAAAgyGAAAsyr MA0051.1 sGAAAGyGAAAsyrwwwm MA0051.2 sGAAAGyGAAAsyrww |
| Binding Sites: | MA0051.1.1 MA0051.1.10 MA0051.1.11 MA0051.1.12 MA0051.1.2 MA0051.1.3 MA0051.1.4 MA0051.1.5 MA0051.1.6 MA0051.1.7 MA0051.1.8 MA0051.1.9 MA0051.2.1 MA0051.2.10 MA0051.2.11 MA0051.2.12 MA0051.2.2 MA0051.2.3 MA0051.2.4 MA0051.2.5 MA0051.2.6 MA0051.2.7 MA0051.2.8 MA0051.2.9 |
| Publications: | Tanaka N., Kawakami T., Taniguchi T. Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Mol. Cell. Biol. 13:4531-4538 (1993). [Pubmed] |
| Related annotations: | PaperBLAST |
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