Transcription Factor
| Accessions: | T012450_1.02 (CISBP 1.02), O49687 (JASPAR 2024) |
| Names: | MYC4, T012450_1.02;, AtbHLH4, AtMYC4, Basic helix-loop-helix protein 4, bHLH 4, bHLH transcription factor bHLH004, MYC4_ARATH, Transcription factor EN 37, Transcription factor MYC4 |
| Organisms: | Arabidopsis thaliana |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O49687 |
| Notes: | experiment type:PBM, family:bHLH |
| Length: | 589 |
| Pfam Domains: | 63-250 bHLH-MYC and R2R3-MYB transcription factors N-terminal 416-461 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MSPTNVQVTDYHLNQSKTDTTNLWSTDDDASVMEAFIGGGSDHSSLFPPLPPPPLPQVNE 60 61 DNLQQRLQALIEGANENWTYAVFWQSSHGFAGEDNNNNNTVLLGWGDGYYKGEEEKSRKK 120 121 KSNPASAAEQEHRKRVIRELNSLISGGVGGGDEAGDEEVTDTEWFFLVSMTQSFVKGTGL 180 181 PGQAFSNSDTIWLSGSNALAGSSCERARQGQIYGLQTMVCVATENGVVELGSSEIIHQSS 240 241 DLVDKVDTFFNFNNGGGEFGSWAFNLNPDQGENDPGLWISEPNGVDSGLVAAPVMNNGGN 300 301 DSTSNSDSQPISKLCNGSSVENPNPKVLKSCEMVNFKNGIENGQEEDSSNKKRSPVSNNE 360 361 EGMLSFTSVLPCDSNHSDLEASVAKEAESNRVVVEPEKKPRKRGRKPANGREEPLNHVEA 420 421 ERQRREKLNQRFYSLRAVVPNVSKMDKASLLGDAISYISELKSKLQKAESDKEELQKQID 480 481 VMNKEAGNAKSSVKDRKCLNQESSVLIEMEVDVKIIGWDAMIRIQCSKRNHPGAKFMEAL 540 541 KELDLEVNHASLSVVNDLMIQQATVKMGNQFFTQDQLKVALTEKVGECP |
| Interface Residues: | 417, 418, 420, 421, 424, 425, 429, 445, 447 |
| 3D-footprint Homologues: | 7d8t_A, 4zpk_A, 7xq5_A, 5nj8_D, 7f2f_B, 5eyo_A, 5v0l_A, 7ssa_L, 5gnj_I, 6g1l_A, 4h10_A, 7xi3_A, 5i50_B, 8osl_P, 1an4_A, 7z5k_B |
| Binding Motifs: | MA0569.1 rCACGTGC M0160_1.02 mrCACGTGyk MA0569.2 CACGTGC |
| Publications: | Fernández-Calvo P, Chini A, Fernández-Barbero G, Chico J.M, Gimenez-Ibanez S, Geerinck J, Eeckhout D, Schweizer F, Godoy M, Franco-Zorrilla J.M, Pauwels L, Witters E, Puga M.I, Paz-Ares J, Goossens A, Reymond P, De Jaeger G, Solano R. The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses. The Plant cell 23:701-15 (2011). [Pubmed] |
| Related annotations: | PaperBLAST |
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