Transcription Factor
Accessions: | T118452_1.02 (CISBP 1.02), MYB_MOUSE (HOCOMOCO 10), P06876 (JASPAR 2024) |
Names: | Myb, T118452_1.02;, MYB_MOUSE, Proto-oncogene c-Myb, Transcriptional activator Myb |
Organisms: | Mus musculus |
Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | P06876 |
Notes: | experiment type:PBM, family:Myb/SANT |
Length: | 636 |
Pfam Domains: | 40-86 Myb-like DNA-binding domain 43-103 Myb-like DNA-binding domain 92-138 Myb-like DNA-binding domain 95-152 Myb-like DNA-binding domain 145-188 Myb-like DNA-binding domain 147-201 Myb-like DNA-binding domain 266-313 LMSTEN motif 401-562 C-myb, C-terminal |
Sequence: (in bold interface residues) | 1 MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT 60 61 DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK 120 121 HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA 180 181 IKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPPSQLSPSGQSSV 240 241 NSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL 300 301 LLMSTENELKGQQALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVSCLGEHHATPSLPAD 360 361 PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHESSGLDAPTLP 420 421 STPLIGHKLTPCRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPL 480 481 KMLPQTPSHAVEDLQDVIKQESDESGIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSN 540 541 HWAENSLSTQLFSQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPC 600 601 SGAWEPASCGKTEDQMTASGPARKYVNAFSARTLVM |
Interface Residues: | 40, 75, 76, 77, 79, 80, 83, 84, 85, 126, 127, 128, 129, 131, 132, 136, 137, 164, 173, 178, 179, 182, 183, 186, 187, 188 |
3D-footprint Homologues: | 3osg_A, 7c4r_A, 1vfc_A, 1w0t_A, 1ign_A, 5eyb_B, 7xur_A, 2kdz_A, 3zqc_A, 6kks_A, 1mse_C, 7el3_B |
Binding Motifs: | PB0045.1 wtkdmAACCGTTAwwht PB0149.1 bgaccAACTGcCrysy MA0100.2 yyAACTGyCW M1356_1.02 wwrdCCGTTr MYB_MOUSE.H10MO.C|M01217 gtggCaGTTrg MA0100.1 grCvGTTG |
Binding Sites: | MA0100.2.1 MA0100.2.10 MA0100.2.11 MA0100.2.12 MA0100.2.13 MA0100.2.14 MA0100.2.15 MA0100.2.16 MA0100.2.17 MA0100.2.18 MA0100.2.19 MA0100.2.2 MA0100.2.20 MA0100.2.3 MA0100.2.4 MA0100.2.5 MA0100.2.6 MA0100.2.7 MA0100.2.8 MA0100.2.9 |
Publications: | Howe K. M., Watson R. J. Nucleotide preferences in sequence-specific recognition of DNA by c-myb protein. Nucleic Acids Res. 19:3913-3919 (1991). [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Frampton J, Kouzarides T, Döderlein G, Graf T, Weston K. Influence of the v-Myb transactivation domain on the oncoprotein's transformation specificity. The EMBO journal 12:1333-41 (1993). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.