Transcription Factor

Accessions: T118452_1.02 (CISBP 1.02), MYB_MOUSE (HOCOMOCO 10), P06876 (JASPAR 2024)
Names: Myb, T118452_1.02;, MYB_MOUSE, Proto-oncogene c-Myb, Transcriptional activator Myb
Organisms: Mus musculus
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P06876
Notes: experiment type:PBM, family:Myb/SANT
Length: 636
Pfam Domains: 40-86 Myb-like DNA-binding domain
43-103 Myb-like DNA-binding domain
92-138 Myb-like DNA-binding domain
95-152 Myb-like DNA-binding domain
145-188 Myb-like DNA-binding domain
147-201 Myb-like DNA-binding domain
266-313 LMSTEN motif
401-562 C-myb, C-terminal
Sequence:
(in bold interface residues)
1 MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT 60
61 DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK 120
121 HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA 180
181 IKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPPSQLSPSGQSSV 240
241 NSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL 300
301 LLMSTENELKGQQALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVSCLGEHHATPSLPAD 360
361 PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHESSGLDAPTLP 420
421 STPLIGHKLTPCRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPL 480
481 KMLPQTPSHAVEDLQDVIKQESDESGIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSN 540
541 HWAENSLSTQLFSQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPC 600
601 SGAWEPASCGKTEDQMTASGPARKYVNAFSARTLVM
Interface Residues: 40, 75, 76, 77, 79, 80, 83, 84, 85, 126, 127, 128, 129, 131, 132, 136, 137, 164, 173, 178, 179, 182, 183, 186, 187, 188
3D-footprint Homologues: 3osg_A, 7c4r_A, 1vfc_A, 1w0t_A, 1ign_A, 5eyb_B, 7xur_A, 2kdz_A, 3zqc_A, 6kks_A, 1mse_C, 7el3_B
Binding Motifs: PB0045.1 wtkdmAACCGTTAwwht
PB0149.1 bgaccAACTGcCrysy
MA0100.2 yyAACTGyCW
M1356_1.02 wwrdCCGTTr
MYB_MOUSE.H10MO.C|M01217 gtggCaGTTrg
MA0100.1 grCvGTTG
Binding Sites: MA0100.2.1
MA0100.2.10
MA0100.2.11
MA0100.2.12
MA0100.2.13
MA0100.2.14
MA0100.2.15
MA0100.2.16
MA0100.2.17
MA0100.2.18
MA0100.2.19
MA0100.2.2
MA0100.2.20
MA0100.2.3
MA0100.2.4
MA0100.2.5
MA0100.2.6
MA0100.2.7
MA0100.2.8
MA0100.2.9
Publications: Howe K. M., Watson R. J. Nucleotide preferences in sequence-specific recognition of DNA by c-myb protein. Nucleic Acids Res. 19:3913-3919 (1991). [Pubmed]

Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

Frampton J, Kouzarides T, Döderlein G, Graf T, Weston K. Influence of the v-Myb transactivation domain on the oncoprotein's transformation specificity. The EMBO journal 12:1333-41 (1993). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.