Transcription Factor
| Accessions: | PO3F1_HUMAN (HOCOMOCO 10), Q03052 (JASPAR 2024) |
| Names: | Oct-6, Octamer-binding protein 6, Octamer-binding transcription factor 6, OTF-6, PO3F1_HUMAN, POU domain transcription factor SCIP, POU domain, class 3, transcription factor 1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q03052 |
| Length: | 451 |
| Pfam Domains: | 248-321 Pou domain - N-terminal to homeobox domain 340-396 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MATTAQYLPRGPGGGAGGTGPLMHPDAAAAAAAAAAAERLHAGAAYREVQKLMHHEWLGA 60 61 GAGHPVGLAHPQWLPTGGGGGGDWAGGPHLEHGKAGGGGTGRADDGGGGGGFHARLVHQG 120 121 AAHAGAAWAQGSTAHHLGPAMSPSPGASGGHQPQPLGLYAQAAYPGGGGGGLAGMLAAGG 180 181 GGAGPGLHHALHEDGHEAQLEPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHPGAGGGGSS 240 241 VGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQ 300 301 LSFKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLK 360 361 CPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPG 420 421 GGGASPPSAPPPPPPAALHHHHHHTLPGSVQ |
| Interface Residues: | 273, 289, 290, 291, 292, 294, 295, 301, 305, 338, 340, 341, 342, 343, 381, 382, 384, 385, 388, 389, 392, 393, 396 |
| 3D-footprint Homologues: | 7u0g_M, 3d1n_M, 3l1p_A, 1o4x_A, 2xsd_C, 1e3o_C, 7xrc_C, 1au7_A, 8g87_X, 3lnq_A, 3cmy_A, 2h1k_B, 1ig7_A, 1puf_A, 1fjl_B, 5zfz_A, 2lkx_A, 1nk2_P, 1jgg_B, 1zq3_P, 3rkq_B, 2r5y_A, 5hod_A, 7psx_B, 4xrs_G, 3a01_E, 5jlw_D, 2ld5_A, 7q3o_C, 1le8_A, 1b72_A, 5flv_I, 5zjt_E, 1du0_A, 2hdd_A, 6es3_K, 4cyc_A |
| Binding Motifs: | MA0786.1 wTATGywAATkw PO3F1_HUMAN.H10MO.C|M01446 vrTkswwATGCaww MA0786.2 wTATGywAAT |
| Publications: | Verrijzer C. P., Alkema M. J., van Weperen W. W., van Leeuwen H. C., Strating M. J. J., van der Vliet P. C. The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J. 11:4993-5003 (1992). [Pubmed] |
| Related annotations: | PaperBLAST |
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