Transcription Factor

						

			
Accessions: Q95216 (JASPAR 2024)

			
Names: EC 2.3.2.27, EC 3.6.4.-, Helicase-like transcription factor, HLTF_RABIT, RING-type E3 ubiquitin transferase HLTF, RUSH-1, Sucrose nonfermenting protein 2-like 3, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3
Organisms: Oryctolagus cuniculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q95216
Length: 1005
Pfam Domains:    61-153 HIRAN domain
  243-718 SNF2 family N-terminal domain
  754-799 Zinc finger, C3HC4 type (RING finger)
  755-799 Ring finger domain
  757-797 Zinc finger, C3HC4 type (RING finger)
  868-947 Helicase conserved C-terminal domain
Sequence: 
(in bold interface residues)		   1 MSWMFKRDPVWKYLQTVQYGVHGNFSRLSYPTFFPRFEFQDIIPPDDFLTSDEELDSVLF   60
  61 GTLRGHVVGLRYYTGVVNNNEMVALQREPNNPYDKNAIKVNNVNGNQVGYLKKELAAALA  120
 121 YIMDNKLAQIEGVVPYGANNAFTMPLQMTFWGKEENRKAVLDQLKKHGFKLGPAPKTLGF  180
 181 SLESGWGSGRAGPSYSMPVHAAIQMTTEQLKTEFDKLFEDLKEDDKTQEMEPAEAVETPL  240
 241 LPHQKQALAWMVSRENSRELPPFWELRNDLYYNTITNFSEKDQPENVHGGILADDMGLGK  300
 301 TLTAIAVILTNFHDGKPLPVERMKKNQVKKECNSSESDKPGRKDTIKKTDGLSKEGSRYS  360
 361 EEPSISDVKKNKYSMSELSSSQPKRKKIAVQYIESSDSEEIEISELPQKMKGKLKNVQSE  420
 421 TKRVKVGPSKIKEDTAFACALTSSASTTTKKILKKGASAQRVQRKLMFEERPRTTLIICP  480
 481 LSVLSNWIDQFGQHIKSDVHLNFYVYYGPDRIRDPALLSKQDIVLTTYNILTHDYGTKGD  540
 541 SPLHSIRWLRVILDEGHAIRNPNAQQTKAVLDLEAERRWVLTGTPIQNSLKDLWSLLSFL  600
 601 KLKPFVDREWWHRTIQRPVTMGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPERPV  660
 661 FIQHITLSDEERKIYQSVKSEGKATIGRYFNEGTVLAHYADVLGLLLRLRQICCHTHLLT  720
 721 NTVSSSGPSGNDTPEELRKKLIKKMKLILSSGSDEECAICLDSLTVPVITHCAHVFCKPC  780
 781 ICQCIQNEQPHAKCPLCRNDIHGDNLLECPPEELACDSEKKSNMEWTSSSKINALMHALI  840
 841 DLRTKNPNIKSLVVSQFTTFLSLIETPLKASGFVFTRLDGSMAQKKRVESIQCFQNTEAG  900
 901 SPTIMLLSLKAGGVGLNLCAASRVFLMDPAWNPAAEDQRFDRCHRLGQKQEVIITKFIVK  960
 961 DSVEENMLKIQNTKRELAAGAFGTKKNANEMKQAKINEIRTLIDL
Interface Residues: 72, 73, 91, 93, 110, 533, 881, 910, 930, 931, 970
3D-footprint Homologues: 4xzf_A, 1z63_A, 6kw4_Y, 6ryu_V, 5vvr_M
Binding Motifs: MA0109.1 / UN0669.1 wwmCwTwkvt
			
Publications: Hewetson A, Hendrix E.C, Mansharamani M, Lee V.H, Chilton B.S. Identification of the RUSH consensus-binding site by cyclic amplification and selection of targets: demonstration that RUSH mediates the ability of prolactin to augment progesterone-dependent gene expression. Molecular endocrinology (Baltimore, Md.) 16:2101-12 (2002). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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