Transcription Factor

						

			
Accessions: HSF1_HUMAN (HOCOMOCO 10), Q00613 (JASPAR 2024)

			
Names: Heat shock factor protein 1, Heat shock transcription factor 1, HSF 1, HSF1_HUMAN, HSTF 1
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 529
Pfam Domains:    17-120 HSF-type DNA-binding
  246-529 Vertebrate heat shock transcription factor
Sequence: 
(in bold interface residues)		   1 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY   60
  61 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT  120
 121 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA  180
 181 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY  240
 241 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE  300
 301 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR  360
 361 PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP  420
 421 SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGS  480
 481 VDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
Interface Residues: 62, 63, 68, 70, 71, 72, 74, 75, 117
3D-footprint Homologues: 5hdn_C, 5d5v_B, 5d5w_B, 3hts_B, 7dci_A
Binding Motifs: MA0486.2 TTCTaGAAyrTTC
MA0486.1 yTTCyrGAAsbTTCy
HSF1_HUMAN.H10MO.A|M01229 rGAArrttCyaGAA
Binding Sites: MA0486.1.1
MA0486.1.10
MA0486.1.11
MA0486.1.12
MA0486.1.13
MA0486.1.14
MA0486.1.15
MA0486.1.16
MA0486.1.17
MA0486.1.18
MA0486.1.19
MA0486.1.2
MA0486.1.20
MA0486.1.3
MA0486.1.4
MA0486.1.5
MA0486.1.6
MA0486.1.7
MA0486.1.8
MA0486.1.9
			
Publications: Reddy T.E, DeLisi C, Shakhnovich B.E. Binding site graphs: a new graph theoretical framework for prediction of transcription factor binding sites. PLoS computational biology 3:e90 (2007). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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