Transcription Factor
| Accessions: | ETS1_HUMAN (HOCOMOCO 10), P14921 (JASPAR 2024) |
| Names: | ETS1_HUMAN, p54, Protein C-ets-1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 441 |
| Pfam Domains: | 54-135 Sterile alpha motif (SAM)/Pointed domain 335-416 Ets-domain |
| Sequence: (in bold interface residues) | 1 MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQ 60 61 QRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKDCFLELAPDF 120 121 VGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSF 180 181 ITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVTPDNMCMGR 240 241 TSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKP 300 301 KGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDG 360 361 WEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQS 420 421 LLGYTPEELHAMLDVKPDADE |
| Interface Residues: | 332, 387, 388, 390, 391, 392, 394, 395, 409 |
| 3D-footprint Homologues: | 3zp5_A, 7jsa_J, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B |
| Binding Motifs: | MA0098.3 ACCGGAWrTr ETS1_HUMAN.H10MO.C|M01123 acmGGAWgt MA0098.1 ywTCCk MA0098.4 ACCGGAWrT |
| Binding Sites: | MA0098.1.1 MA0098.1.10 MA0098.1.11 MA0098.1.12 MA0098.1.13 MA0098.1.14 MA0098.1.15 MA0098.1.16 MA0098.1.17 MA0098.1.18 MA0098.1.19 MA0098.1.2 MA0098.1.20 MA0098.1.3 MA0098.1.4 MA0098.1.5 MA0098.1.6 MA0098.1.7 MA0098.1.8 MA0098.1.9 |
| Publications: | Woods D. B., Ghysdael J., Owen M. J. Identification of nucleotide preferences in DNA sequences recognised specifially by c-Ets-1 protein. Nucleic Acids Res. 20:699-704 (1992). [Pubmed] Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] |
| Related annotations: | PaperBLAST |
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