Transcription Factor

						

			
Accessions: 1b3t_A (3D-footprint 20231221), 1b3t_B (3D-footprint 20231221), 6pw2_A (3D-footprint 20231221), 6pw2_B (3D-footprint 20231221), 6pw2_C (3D-footprint 20231221), 6pw2_D (3D-footprint 20231221), 6pw2_I (3D-footprint 20231221), 6pw2_J (3D-footprint 20231221), 6pw2_K (3D-footprint 20231221), 6pw2_L (3D-footprint 20231221)

			
Names: EBNA-1, EBNA1_EBVB9, EBV nuclear antigen 1, Epstein-Barr nuclear antigen 1, NUCLEAR PROTEIN EBNA1
Organisms: Epstein-Barr virus (strain B95-8) (HHV-4), Human herpesvirus 4
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P03211
Length: 147
Pfam Domains:     1-146 Epstein Barr virus nuclear antigen-1, DNA-binding domain
Sequence: 
(in bold interface residues)		   1 KGGWFGKHRGQGGSNPKFENIAEGLRALLARSHVERTTDEGTWVAGVFVYGGSKTSLYNL   60
  61 RRGTALAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFMVFLQTHIFAEVLKDAIK  120
 121 DLVMTKPAPTCNIRVTVCSFDDGVDLP
Interface Residues: 1, 4, 5, 9, 17, 54, 55, 58, 59, 62
3D-footprint Homologues: 7u1t_B, 5t7x_B
Binding Motifs: 1b3t_A GCTTCCC
1b3t_AB GGGAAGCaTAnGCTTCCC
6pw2_ABCD ATAGCnnnTnTTnCCCnnnGGGnAGmnnnnnCTATC
6pw2_B GATAGca
6pw2_IJKL AATAGCATnTnTTACCCnnnGGGAAGCnnnnGnTAT
Binding Sites: 1b3t_C / 1b3t_D
6pw2_E
6pw2_F
6pw2_G
6pw2_H
			
Publications: Bochkarev A, Bochkareva E, Frappier L, Edwards A.M. The 2.2 A structure of a permanganate-sensitive DNA site bound by the Epstein-Barr virus origin binding protein, EBNA1. Journal of molecular biology 284:1273-8 (1998). [Pubmed]


Malecka KA, Dheekollu J, Deakyne JS, Wiedmer A, Ramirez UD, Lieberman PM, Messick TE. Structural Basis for Cooperative Binding of EBNA1 to the Epstein-Barr Virus Dyad Symmetry Minimal Origin of Replication. J Virol : (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.