Transcription Factor

						

			
Accessions: P32242 (JASPAR 2024)

			
Names: Homeobox protein OTX1, Orthodenticle homolog 1, OTX1_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 354
Pfam Domains:     39-95 Homeobox domain
  178-280 Otx1 transcription factor
Sequence: 
(in bold interface residues)		   1 MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKT   60
  61 RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSG  120
 121 SESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPA  180
 181 SISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSS  240
 241 SYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHH  300
 301 HQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQVL
Interface Residues: 38, 39, 40, 41, 42, 80, 81, 83, 84, 87, 88, 91, 92, 95
3D-footprint Homologues: 4j19_B, 2h1k_B, 1puf_A, 3d1n_M, 5zfz_A, 1fjl_B, 1ig7_A, 6a8r_A, 3cmy_A, 1jgg_B, 2lkx_A, 6m3d_C, 1nk2_P, 1zq3_P, 3lnq_A, 7q3o_C, 6es3_K, 2ld5_A, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1au7_A, 4cyc_A, 2r5y_A, 1puf_B, 5flv_I, 3l1p_A, 2hos_A, 1b72_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 1e3o_C, 1le8_A, 8g87_X, 1o4x_A, 1du0_A, 4qtr_D
Binding Motifs: MA0711.1 yTAATCcs
MA0711.2 TAATCc
			
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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