Transcription Factor

Accessions: Q9ULV5 (JASPAR 2024)
Names: Heat shock factor protein 4, Heat shock transcription factor 4, hHSF4, HSF 4, HSF4_HUMAN, HSTF 4
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9ULV5
Length: 492
Pfam Domains: 19-121 HSF-type DNA-binding
Sequence:
(in bold interface residues)
1 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP 60
61 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK 120
121 VPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHGQ 180
181 QHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPYF 240
241 IQSPLPETNLGLSPHRARGPIISDIPEDSPSPEGTRLSPSSDGRREKGLALLKEEPASPG 300
301 GDGEAGLALAPNECDFCVTAPPPLPVAVVQAILEGKGSFSPEGPRNAQQPEPGDPREIPD 360
361 RGPLGLESGDRSPESLLPPMLLQPPQESVEPAGPLDVLGPSLQGREWTLMDLDMELSLMQ 420
421 PLVPERGEPELAVKGLNSPSPGKDPTLGAPLLLDVQAALGGPALGLPGALTIYSTPESRT 480
481 ASYLGPEASPSP
Interface Residues: 64, 65, 70, 72, 73, 74, 76, 77, 119
3D-footprint Homologues: 5hdn_C, 5d5v_B, 5d5w_B, 3hts_B, 7dci_A
Binding Motifs: MA0771.1 TTCtrGAAyrTTC
Publications: Funikov SIu, Garbuz DG, Zatsepina OG. [Kinetics of heat shock response upon disfunction of general transcription factor (HSF)]. Mol Biol (Mosk) 48:306-13 (2014). [Pubmed]
Related annotations: PaperBLAST

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