Transcription Factor

						

			
Accessions: TFEB_HUMAN (HOCOMOCO 10), P19484 (JASPAR 2024)

			
Names: bHLHe35, Class E basic helix-loop-helix protein 35, TFEB_HUMAN, Transcription factor EB
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 476
Pfam Domains:   236-289 Helix-loop-helix DNA-binding domain
  321-474 Domain of unknown function (DUF3371)
Sequence: 
(in bold interface residues)		   1 MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQ   60
  61 SPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPA  120
 121 ASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQM  180
 181 PNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNH  240
 241 NLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELEN  300
 301 HSRRLEMTNKQLWLRIQELEMQARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEAL  360
 361 MLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPG  420
 421 HGSPFPSLSKKDLDLMLLDDSLLPLASDPLLSTMSPEASKASSRRSSFSMEEGDVL
Interface Residues: 237, 239, 240, 241, 243, 244, 247, 248, 272, 274
3D-footprint Homologues: 1a0a_B, 1an4_A, 7f2f_B, 5i50_B, 1am9_A, 4zpk_A, 7ssa_L, 6g1l_A, 5eyo_A, 7xi3_A, 5nj8_D, 4h10_A, 7d8t_A, 5gnj_I, 8osl_O, 5v0l_A, 4h10_B, 8osl_P, 5nj8_C, 5v0l_B
Binding Motifs: MA0692.1 ryCACGTGAy
TFEB_HUMAN.H10MO.C|M01575 rRTCACGTG
MA0692.2 CACGTGAy
			
Publications: Fisher D. E., Carr C. S., Parent L. A., Sharp P. A. TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine zipper family. Genes Dev. 5:2342-2352 (1991). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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