Transcription Factor

Accessions: CREB1 (HT-SELEX2 May2017)
Names: CREB1, ENSG00000118260
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 119
Pfam Domains: 59-116 bZIP transcription factor
64-111 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 QYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEA 60
61 ARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Interface Residues: 71, 72, 74, 75, 78, 79
3D-footprint Homologues: 5t01_B, 5vpe_D, 7x5e_F, 1dh3_C
Binding Motifs: CREB1_4 srTGACGTr
CREB1_5 crTkACGTmAys
CREB1_6 rtgaCryGTcAy
CREB1_8 srTgACGTcAys
CREB1_methyl_1 srTGAyGTCAyg
CREB1_methyl_2 brTGACGyr
CREB1_methyl_3 srTGAyGYGtd
CREB1_methyl_7 brTGAyGTCAyv
Related annotations: PaperBLAST

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