Transcription Factor
| Accessions: | CRX_MOUSE (HOCOMOCO 10), O54751 (JASPAR 2024) |
| Names: | CRX_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 299 |
| Pfam Domains: | 40-96 Homeobox domain 164-250 Otx1 transcription factor |
| Sequence: (in bold interface residues) | 1 MMAYMNPGPHYSVNALALSGPNVDLMHQAVPYSSAPRKQRRERTTFTRSQLEELEALFAK 60 61 TQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGAQTKARPAKRK 120 121 AGTSPRPSTDVCTDPLGISDSYSPSLPGPSGSPTTAVATVSIWSPASEAPLPEAQRAGLV 180 181 ASGPSLTSAPYAMTYAPASAFCSSPSAYASPSSYFSGLDPYLSPMVPQLGGPALSPLSGP 240 241 SVGPSLAQSPTSLSGQSYSTYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL |
| Interface Residues: | 39, 40, 41, 42, 43, 81, 82, 84, 85, 88, 89, 92, 93, 96, 100 |
| 3D-footprint Homologues: | 4j19_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 2hos_A, 1b72_A, 4cyc_A, 6m3d_C, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 7xrc_C, 2xsd_C, 1e3o_C, 1le8_A, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D |
| Binding Motifs: | MA0467.1 aAGrGGATTAr CRX_MOUSE.H10MO.A|M01044 wragrrGATTAr PH0015.1 ykwwGsGGATTArCck MA0467.2 grGGATTArv MA0467.3 GGATTA |
| Binding Sites: | MA0467.1.1 MA0467.1.10 MA0467.1.11 MA0467.1.12 MA0467.1.13 MA0467.1.14 MA0467.1.15 MA0467.1.16 MA0467.1.17 MA0467.1.18 MA0467.1.19 MA0467.1.2 MA0467.1.20 MA0467.1.3 MA0467.1.4 MA0467.1.5 MA0467.1.6 MA0467.1.7 MA0467.1.8 MA0467.1.9 MA0467.3.1 / MA0467.3.10 / MA0467.3.11 / MA0467.3.12 / MA0467.3.13 / MA0467.3.14 / MA0467.3.15 / MA0467.3.16 / MA0467.3.18 / MA0467.3.2 / MA0467.3.20 / MA0467.3.4 / MA0467.3.7 / MA0467.3.8 / MA0467.3.9 MA0467.2.1 MA0467.2.10 / MA0467.2.2 / MA0467.2.8 MA0467.2.11 / MA0467.2.9 MA0467.2.10 / MA0467.2.12 MA0467.2.11 / MA0467.2.13 / MA0467.2.3 / MA0467.2.4 MA0467.2.12 / MA0467.2.14 MA0467.2.13 / MA0467.2.15 MA0467.2.14 / MA0467.2.16 MA0467.2.17 MA0467.2.15 / MA0467.2.18 MA0467.2.19 MA0467.2.16 / MA0467.2.20 MA0467.2.3 MA0467.2.5 MA0467.2.6 MA0467.2.5 / MA0467.2.7 MA0467.2.6 / MA0467.2.8 MA0467.2.7 / MA0467.2.9 MA0467.3.17 MA0467.2.17 MA0467.2.18 MA0467.2.19 MA0467.2.20 MA0467.2.4 MA0467.3.19 / MA0467.3.3 MA0467.3.5 MA0467.3.6 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Lee J, Myers C.A, Williams N, Abdelaziz M, Corbo J.C. Quantitative fine-tuning of photoreceptor cis-regulatory elements through affinity modulation of transcription factor binding sites. Gene therapy 17:1390-9 (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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