Transcription Factor

Accessions: 5cbx_A (3D-footprint 20210203)
Names: AncGR DNA Binding Domain, GCR_HUMAN, Glucocorticoid receptor, Nuclear receptor subfamily 3 group C member 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20210203 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P04150
Length: 72
Pfam Domains: 2-69 Zinc finger, C4 type (two domains)
Sequence:
(in bold interface residues)
1 KICLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRF 60
61 RKCLQAGMNLEA
Interface Residues: 11, 12, 14, 15, 21, 22, 24, 25, 28, 29, 53
3D-footprint Homologues: 6fbq_A, 6l6q_B, 1lo1_A, 1a6y_A, 3g9m_B, 4oln_B, 4nqa_H, 2nll_A, 5uan_B, 3e00_A, 2ff0_A, 1hcq_E, 4nqa_I, 2nll_B, 4umm_E, 2han_A, 1kb2_B, 5krb_G, 3cbb_A, 1ynw_B, 1dsz_A, 4iqr_B, 2han_B, 1lat_A, 5l0m_A, 4ond_A, 3dzy_D, 4tnt_B, 5emc_A, 1r4i_A, 5va7_A, 5cbz_E, 2c7a_B, 1glu_A, 5e69_A
Binding Motifs: 5cbx_AB GnnCAnnnTGTnC
Publications: Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed]
Related annotations: PaperBLAST

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