Transcription Factor
| Accessions: | T144624_1.02 (CISBP 1.02), P40646 (JASPAR 2024) |
| Names: | Sox7, T144624_1.02;, mSOX7, SOX7_MOUSE, Transcription factor SOX-7 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Sox |
| Length: | 380 |
| Pfam Domains: | 45-113 HMG (high mobility group) box 45-106 Domain of unknown function (DUF1898) 172-379 Sox C-terminal transactivation domain |
| Sequence: (in bold interface residues) | 1 MASLLGAYPWTEGLECPALEAELSDGLSPPAVPRPSGDKSSESRIRRPMNAFMVWAKDER 60 61 KRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYKYRPRRKK 120 121 QGKRLCKRVDPGFLLSSLSRDQNTLPEKNGIGRGEKEDRGEYSPGATLPGLHSCYREGAA 180 181 AAPGSVDTYPYGLPTPPEMSPLDALEPEQTFFSSSCQEEHGHPHHLPHLPGPPYSPEFTP 240 241 SPLHCSHPLGSLALGQSPGVSMMSSVSGCPPSPAYYSHATYHPLHPNLQAHLGQLSPPPE 300 301 HPGFDTLDQLSQVELLGDMDRNEFDQYLNTPGHPDSAAGVGTLTGHVPLSQGTPTGPTET 360 361 SLISVLADATATYYNSYSVS |
| Interface Residues: | 47, 50, 52, 53, 56, 60, 71, 72, 73, 76, 114, 118, 132, 133, 135, 136, 137, 139, 140 |
| 3D-footprint Homologues: | 4y60_C, 2lef_A, 1o4x_B, 6jrp_D, 3u2b_C, 1qrv_A, 7m5w_A, 3f27_D, 4s2q_D, 2gzk_A, 3tmm_A, 1j5n_A, 3tq6_B, 1hry_A, 2v6e_B |
| Binding Motifs: | PB0073.1 mwtrwwrAACAATarawythyw PB0177.1 gtsswaATTrwstgwgkrcksy M1600_1.02 ATTgTtyt MA2095.1 aGAACAATGG |
| Binding Sites: | MA2095.1.11 / MA2095.1.12 / MA2095.1.15 MA2095.1.18 MA2095.1.1 / MA2095.1.10 / MA2095.1.19 MA2095.1.13 MA2095.1.14 MA2095.1.16 MA2095.1.17 MA2095.1.2 MA2095.1.20 MA2095.1.3 MA2095.1.4 MA2095.1.5 MA2095.1.6 / MA2095.1.7 MA2095.1.8 MA2095.1.9 |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Niimi T., Hayashi Y., Futaki S., Sekiguchi K. SOX7 and SOX17 regulate the parietal endoderm-specific enhancer activity of mouse laminin alpha1 gene. J. Biol. Chem. 279:38055-61 (2004). [Pubmed] |
| Related annotations: | PaperBLAST |
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