Transcription Factor
| Accessions: | T081992_1.02 (CISBP 1.02), FOXO1_MOUSE (HOCOMOCO 10), Q9R1E0 (JASPAR 2024) |
| Names: | Foxo1, T081992_1.02;, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FOXO1_MOUSE |
| Organisms: | Mus musculus, Homo sapiens |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9R1E0 |
| Notes: | experiment type:PBM, family:Forkhead |
| Length: | 652 |
| Pfam Domains: | 160-242 Fork head domain |
| Sequence: (in bold interface residues) | 1 MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEFNQSNSTTSSPAPSGGAAANPDAAASLAS 60 61 ASAVSTDFMSNLSLLEESEDFARAPGCVAVAAAAAASRGLCGDFQGPEAGCVHPAPPQPP 120 121 PTGPLSQPPPVPPSAAAAAGPLAGQPRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTL 180 181 SQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEG 240 241 GKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQEGPGDSPGSQFSKWPASPGSHS 300 301 NDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAKMASTLPSLS 360 361 EISNPENMENLLDNLNLLSSPTSLTVSTQSSPGSMMQQTPCYSFAPPNTSLNSPSPNYSK 420 421 YTYGQSSMSPLPQMPMQTLQDSKSSYGGLNQYNCAPGLLKELLTSDSPPHNDIMSPVDPG 480 481 VAQPNSRVLGQNVMMGPNSVMPAYGSQASHNKMMNPSSHTHPGHAQQTASVNGRTLPHVV 540 541 NTMPHTSAMNRLTPVKTPLQVPLSHPMQMSALGSYSSVSSCNGYGRMGVLHQEKLPSDLD 600 601 GMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG |
| Interface Residues: | 202, 205, 207, 208, 209, 211, 212, 213, 215, 216, 225, 230, 249, 266 |
| 3D-footprint Homologues: | 3l2c_A, 7vox_H, 2hdc_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 3qrf_G |
| Binding Motifs: | MA0480.1 tsyTGTTTACw M0731_1.02 yrtmAACAa MA1936.1 rwmAACAGGAArks FOXO1_MOUSE.H10MO.C|M01108 rdyTTGTTTwbwwttt MA0480.2 rwGTAAACAva MA0480.3 GTAAACA MA1936.2 rwmAACAGGAAr |
| Binding Sites: | MA0480.3.20 MA0480.2.14 MA0480.3.1 / MA0480.3.2 MA0480.3.12 MA0480.1.1 MA0480.1.10 MA0480.1.11 MA0480.1.12 MA0480.1.13 MA0480.1.14 MA0480.1.15 MA0480.1.16 MA0480.1.17 MA0480.1.18 MA0480.1.19 MA0480.1.2 MA0480.1.20 MA0480.1.3 MA0480.1.4 MA0480.1.5 MA0480.1.6 MA0480.1.7 MA0480.1.8 MA0480.1.9 MA0480.2.10 / MA0480.2.14 MA0480.3.10 / MA0480.3.19 MA0480.2.1 / MA0480.2.2 MA0480.2.11 / MA0480.2.18 MA0480.2.12 / MA0480.2.20 MA0480.2.13 MA0480.2.15 MA0480.2.16 MA0480.2.17 MA0480.2.18 MA0480.2.19 MA0480.2.2 / MA0480.2.3 MA0480.2.20 MA0480.2.3 / MA0480.2.4 MA0480.2.4 / MA0480.2.5 MA0480.2.5 / MA0480.2.7 MA0480.2.6 / MA0480.2.8 MA0480.2.7 / MA0480.2.9 MA0480.2.11 / MA0480.2.8 MA0480.2.13 / MA0480.2.9 MA0480.3.3 MA0480.3.14 / MA0480.3.16 / MA0480.3.6 / MA0480.3.8 MA0480.3.17 MA0480.3.9 MA0480.3.13 / MA0480.3.15 / MA0480.3.4 / MA0480.3.5 / MA0480.3.7 MA0480.2.1 MA0480.2.10 MA0480.2.12 MA0480.2.15 MA0480.2.16 MA0480.2.17 MA0480.2.19 MA0480.2.6 MA0480.3.11 MA0480.3.18 |
| Publications: | Furuyama T., Nakazawa T., Nakano I., Mori N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349:629-634 (2000). [Pubmed] Ibarra IL, Hollmann NM, Klaus B, Augsten S, Velten B, Hennig J, Zaugg JB. Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions. Nat Commun 11:124 (2020). [Pubmed] |
| Related annotations: | PaperBLAST |
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