Transcription Factor
| Accessions: | P81067 (JASPAR 2024) |
| Names: | Homeodomain protein IRXB1, Iroquois homeobox protein 3, Iroquois-class homeodomain protein IRX-3, IRX3_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P81067 |
| Length: | 507 |
| Pfam Domains: | 148-187 Homeobox KN domain 149-190 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSFPQLGYQYIRPLYPPERPGAAGGGGGGSSAGGRSGPGAGASELAASGSLSNVLSSVYG 60 61 APYAAAAAAAAAAQGYGAFLPYATELPIFPQLGAQYELKDSPGVQHPATAAAFPHPHPAF 120 121 YPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTW 180 181 FANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEESKRELEMEEEELAGEE 240 241 EDTGGEGLADDDEDEEIDLENLDSAAAGSELTLAGAAHRNGDFGLGPISDCKTSDSDDSS 300 301 EGLEDRPLSVLSLAPPPPPVARAPASPPSPPSSLDPCAPAPAPSSALQKPKIWSLAETAT 360 361 SPDNPRRSPPGAGGSPPGAAVAPPTLQLSPAAAAAAAAAHRLVSAPLGKFPAWTNRPFPG 420 421 PPAGPRPHPLSMLGSAPQHLLGLPGAAGHPAAAAAAYARPAEPESGTDRCSALEVEKKLL 480 481 KTAFQPVPRRPQNHLDAALVLSALSSS |
| Interface Residues: | 126, 133, 134, 135, 136, 137, 138, 141, 175, 176, 178, 179, 182, 183, 184, 186, 187, 189, 190 |
| 3D-footprint Homologues: | 4cyc_A, 1mnm_C, 6m3d_C, 6fqp_B, 2r5y_A, 2lkx_A, 3d1n_M, 5hod_A, 1fjl_B, 4xrs_G, 1ig7_A, 2h1k_B, 5jlw_D, 2ld5_A, 4xrm_B, 1puf_A, 2hdd_A, 1puf_B, 5zjt_E, 3rkq_B, 1nk2_P, 1b72_A, 7psx_B, 5flv_I, 3a01_E, 2d5v_B, 1k61_B, 1o4x_A, 1du0_A, 3cmy_A, 1le8_B, 6fqq_E, 2hos_A |
| Binding Motifs: | PH0083.1 wrwrTACATGTAawwyw PH0084.1 wwdaTACATGTAawwyw |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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