Transcription Factor
| Accessions: | Q9NVV9 (JASPAR 2024) |
| Names: | THAP1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9NVV9 |
| Length: | 213 |
| Pfam Domains: | 4-84 THAP domain |
| Sequence: (in bold interface residues) | 1 MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKEWEAAVRRKNFKPTKYSSICSEHFTP 60 61 DCFKRECNNKLLKENAVPTIFLCTEPHDKKEDLLEPQEQLPPPPLPPPVSQVDAAIGLLM 120 121 PPLQTPVNLSVFCDHNYTVEDTMHQRKRIHQLEQQVEKLRKKLKTAQQRCRRQERQLEKL 180 181 KEVVHFQKEKDDVSERGYVILPNDYFEIVEVPA |
| Interface Residues: | 1, 3, 24, 32, 41, 47, 48, 50, 51, 52, 65 |
| 3D-footprint Homologues: | 2ko0_A, 5xh6_A |
| Binding Motifs: | MA0597.1 ytGCCMkya MA0597.2 ssgcAGGGCAss MA0597.3 gcAGGGCA |
| Binding Sites: | MA0597.3.6 MA0597.3.20 MA0597.3.8 / MA0597.3.9 MA0597.1.1 MA0597.1.10 MA0597.1.11 MA0597.1.12 MA0597.1.13 MA0597.1.14 MA0597.1.15 MA0597.1.16 MA0597.1.17 MA0597.1.18 MA0597.1.19 MA0597.1.2 MA0597.1.20 MA0597.1.3 MA0597.1.4 MA0597.1.5 MA0597.1.6 MA0597.1.7 MA0597.1.8 MA0597.1.9 MA0597.2.1 MA0597.2.10 MA0597.2.11 MA0597.2.12 MA0597.2.13 MA0597.2.14 MA0597.2.15 MA0597.2.16 MA0597.2.17 MA0597.2.18 MA0597.2.19 MA0597.2.2 MA0597.2.20 MA0597.2.3 MA0597.2.4 MA0597.2.5 MA0597.2.6 MA0597.2.7 MA0597.2.8 MA0597.2.9 MA0597.3.1 / MA0597.3.10 / MA0597.3.12 / MA0597.3.13 / MA0597.3.14 / MA0597.3.17 MA0597.3.11 MA0597.3.15 MA0597.3.16 / MA0597.3.7 MA0597.3.18 / MA0597.3.3 / MA0597.3.4 MA0597.3.19 MA0597.3.2 MA0597.3.5 |
| Publications: | Clouaire T, Roussigne M, Ecochard V, Mathe C, Amalric F, Girard J.P. The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity. Proceedings of the National Academy of Sciences of the United States of America 102:6907-12 (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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