Transcription Factor

						

			
Accessions: Q9BWX5 (JASPAR 2024)

			
Names: GATA-binding factor 5, GATA5_HUMAN, Transcription factor GATA-5
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9BWX5
Length: 397
Pfam Domains:     1-173 GATA-type transcription activator, N-terminal 
  189-222 GATA zinc finger
  243-276 GATA zinc finger
Sequence: 
(in bold interface residues)		   1 MYQSLALAASPRQAAYADSGSFLHAPGAGSPMFVPPARVPSMLSYLSGCEPSPQPPELAA   60
  61 RPGWAQTATADSSAFGPGSPHPPAAHPPGATAFPFAHSPSGPGSGGSAGGRDGSAYQGAL  120
 121 LPREQFAAPLGRPVGTSYSATYPAYVSPDVAQSWTAGPFDGSVLHGLPGRRPTFVSDFLE  180
 181 EFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRAG  240
 241 LCCTNCHTTNTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKTIAKA  300
 301 RGSSGSTRNASASPSAVASTDSSAATSKAKPSLASPVCPGPSMAPQASGQEDDSLAPGHL  360
 361 EFKFEPEDFAFPSTAPSPQAGLRGALRQEAWCALALA
Interface Residues: 198, 199, 201, 211, 215, 252, 253, 255, 265, 269, 270, 273, 290, 292, 293
3D-footprint Homologues: 4hc9_A, 3vd6_C, 1gat_A, 3dfx_B, 4gat_A
Binding Motifs: MA0766.1 wGATAAsr
MA0766.2 cwGATAAsrm
MA0766.3 wGATAAsr
			
Publications: Orkin S.H. GATA-binding transcription factors in hematopoietic cells. Blood 80:575-81 (1992). [Pubmed]


Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol 23:8429-39 (2003). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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