Transcription Factor

Accessions: BHLHE41_full (HumanTF 1.0), Q9C0J9 (JASPAR 2024)
Names: BHE41_HUMAN, bHLHb3, BHLHE41, Class B basic helix-loop-helix protein 3, Class E basic helix-loop-helix protein 41, Differentially expressed in chondrocytes protein 2, Enhancer-of-split and hairy-related protein 1, hDEC2, SHARP-1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Ensembl ID: ENSG00000123095; Full protein sequence; TF family: bHLH; Clone source: hORFeome
Length: 482
Pfam Domains: 49-99 Helix-loop-helix DNA-binding domain
130-172 Hairy Orange
Sequence:
(in bold interface residues)
1 MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKKRRDRI 60
61 NECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSL 120
121 KSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHAVATQFLPTPQLL 180
181 TQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAENDTDTDS 240
241 GYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAA 300
301 AAALLGPDPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAA 360
361 AYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLS 420
421 PPPEKAGAAAATLLPHEVAPLGAPHPQHPHGRTHLPFAGPREPGNPESSAQEDPSQPGKE 480
481 AP
Interface Residues: 49, 50, 52, 53, 56, 57, 83, 85
3D-footprint Homologues: 6g1l_A, 7ssa_L, 1am9_A, 7d8t_A, 4zpk_A, 7xi3_A, 5nj8_D, 7f2f_B, 5eyo_A, 5v0l_A, 4h10_A, 7rcu_E, 5i50_B, 8osl_P, 1an4_A, 4h10_B, 8osl_O, 5nj8_C
Binding Motifs: BHLHE41_full / MA0636.1 rTCACGTGAc
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Nakamura H., Tanimoto K., Hiyama K., Yunokawa M., Kawamoto T., Kato Y., Yoshiga K., Poellinger L., Hiyama E., Nishiyama M. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2.. Oncogene 27:4200-4209 (2008). [Pubmed]
Related annotations: PaperBLAST

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