Transcription Factor

						

			
Accessions: AP2B_HUMAN (HOCOMOCO 10), Q92481 (JASPAR 2024)

			
Names: Activating enhancer-binding protein 2-beta, AP2-beta, AP2B_HUMAN, Transcription factor AP-2-beta
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q92481
Length: 460
Pfam Domains:   228-431 Transcription factor AP-2
Sequence: 
(in bold interface residues)		   1 MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHT   60
  61 PSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQQHPWGQRQRQEVGSEAGS  120
 121 LLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGDSLSLHGLGHPGMEDVQ  180
 181 SVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGFLGGMSVNTGEVFCSVPGRLSLL  240
 241 SSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRR  300
 301 KAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDPSDLHSRKNMLLAT  360
 361 KQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNY  420
 421 LTEALKGMDKMFLNNTTTNRHTSGEGPGSKTGDKEEKHRK
Interface Residues: 241, 275, 276, 440
3D-footprint Homologues: 8j0k_B, 1ubd_C
Binding Motifs: MA0811.1 tgCCyyvrGGCa
MA0812.1 mGCCysAGGCd
MA0813.1 tGCCCybrGGGCa
AP2B_HUMAN.H10MO.B|M01008 GsCyGvGGgs
MA0811.2 gCCyyvrGGCa
MA0812.2 GCCysAGGC
			
Publications: Eckert D, Buhl S, Weber S, Jäger R, Schorle H. The AP-2 family of transcription factors. Genome Biol : (2005;6(13):246.). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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