Transcription Factor
| Accessions: | ZNF519 (humanC2H2ZF-ChIP Feb2015), Q8TB69 (JASPAR 2024) |
| Names: | ENSG00000175322, Q8TB69, ZNF519, ZN519_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 540 |
| Pfam Domains: | 4-43 KRAB box 282-302 Zinc-finger double domain 291-311 C2H2-type zinc finger 292-314 Zinc finger, C2H2 type 292-314 C2H2-type zinc finger 306-330 Zinc-finger double domain 320-342 C2H2-type zinc finger 320-340 C2H2-type zinc finger 320-342 Zinc finger, C2H2 type 335-358 Zinc-finger double domain 348-370 C2H2-type zinc finger 348-368 C2H2-type zinc finger 348-370 Zinc finger, C2H2 type 363-386 Zinc-finger double domain 376-398 C2H2-type zinc finger 376-397 C2H2-type zinc finger 376-398 Zinc finger, C2H2 type 392-414 Zinc-finger double domain 404-426 Zinc finger, C2H2 type 404-426 C2H2-type zinc finger 404-424 C2H2-type zinc finger 418-442 Zinc-finger double domain 432-454 Zinc finger, C2H2 type 432-454 C2H2-type zinc finger 432-452 C2H2-type zinc finger 446-469 Zinc-finger double domain 460-482 Zinc finger, C2H2 type 460-482 C2H2-type zinc finger 460-482 C2H2-type zinc finger 474-499 Zinc-finger double domain 488-510 Zinc finger, C2H2 type 488-510 C2H2-type zinc finger 488-508 C2H2-type zinc finger 502-526 Zinc-finger double domain 516-535 C2H2-type zinc finger 516-538 Zinc finger, C2H2 type 516-538 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MELLTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSLAVYSYYNQGILPEQGIQ 60 61 DSFKKATLGRYGSCGLENICLWKNWESIGEGEGQKECYNLCSQYLTTSHNKHLTVKGDKE 120 121 YRIFQKKPQFLSAAPTEPCIPMNKYQHKFLKSVFCNKNQINFNHDSNISKHHSTHFLENY 180 181 YNCNECEKVFYQSSKLIFPENIHIQKKPYNSNECGETSDPFSKLTQHQRIYIGESSQRCN 240 241 KKCIIVFSQSHLKGHKIINTGEKSVKYKERGKAFTRGLHLGHQKIHTGEKPYKCKKCDKA 300 301 FNKSSHLAQHQRIHTGEKPFKCKECGKAFNRGSYLTQHQRIHTGERAFKCEECGKAFNRG 360 361 SYLTQHQRIHTGEKPFRCKECGKAFNRSSYVTQHQRMHTGEKPFKCKECGKAFNRASHLT 420 421 QHQRIHTGEKHFKCKECGKAFNRGSHLTRHQRIHTGEKSFKCEECGKAFIWGSHLTQHQR 480 481 VHTGEKFFKCKECGKAFTRSSHLTQHQRIHTGEKPFKCKECGKAFNRRSTLTQHQIIHTR 540 |
| Interface Residues: | 250, 254, 278, 303, 304, 305, 306, 308, 309, 313, 330, 331, 332, 333, 334, 336, 337, 348, 358, 359, 360, 361, 362, 364, 365, 367, 368, 371, 386, 387, 388, 389, 390, 392, 393, 414, 415, 416, 417, 418, 420, 421, 422, 442, 443, 444, 445, 446, 447, 448, 449, 450, 452, 455, 469, 471, 472, 473, 474, 477, 481, 498, 499, 500, 501, 502, 503, 505, 526, 527, 529, 530, 532, 533 |
| 3D-footprint Homologues: | 7w1m_H, 2i13_A, 5kkq_D, 1f2i_J, 6wmi_A, 5k5i_A, 8ssq_A, 1g2f_F, 8ssu_A, 7eyi_G, 7ysf_A, 2lt7_A, 5v3j_F, 5ei9_F, 5und_A, 2gli_A, 6ml4_A, 1ubd_C, 2kmk_A, 7n5w_A, 4x9j_A, 6blw_A, 6u9q_A, 8h9h_G, 2jpa_A, 1tf3_A, 6jnm_A, 1llm_D, 2wbs_A, 1mey_C, 7txc_E, 5kl3_A, 2drp_D, 1tf6_A, 6e94_A, 5yel_A, 6a57_A, 4m9v_C, 5yj3_D, 8gn3_A, 3uk3_C, 8cuc_F, 7y3l_A, 5k5l_F, 7y3m_I |
| Binding Motifs: | ZNF519_ChIP CGGAAGws UN0331.1 gcAGCTGCCss UN0331.2 gcAGCTGCC |
| Binding Sites: | UN0331.2.1 / UN0331.2.14 / UN0331.2.15 / UN0331.2.18 / UN0331.2.19 / UN0331.2.3 / UN0331.2.4 / UN0331.2.5 / UN0331.2.7 UN0331.1.1 UN0331.1.10 / UN0331.1.7 UN0331.1.11 UN0331.1.12 / UN0331.1.19 UN0331.1.13 / UN0331.1.8 UN0331.1.14 / UN0331.1.9 UN0331.1.15 UN0331.1.16 UN0331.1.17 UN0331.1.10 / UN0331.1.18 UN0331.1.2 UN0331.1.11 / UN0331.1.20 UN0331.1.3 UN0331.1.2 / UN0331.1.4 UN0331.1.19 / UN0331.1.3 / UN0331.1.5 / UN0331.1.8 UN0331.1.6 UN0331.1.4 / UN0331.1.7 UN0331.1.9 UN0331.1.12 UN0331.1.13 UN0331.1.14 UN0331.1.15 UN0331.1.16 UN0331.1.17 UN0331.1.18 UN0331.1.20 UN0331.1.6 UN0331.2.10 UN0331.2.11 UN0331.2.12 UN0331.2.13 UN0331.2.16 UN0331.2.17 UN0331.2.2 / UN0331.2.8 UN0331.2.20 UN0331.2.6 UN0331.2.9 |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.