Transcription Factor

Accessions: Q96IS3 (JASPAR 2024)
Names: Q50-type retinal homeobox protein, RAX2_HUMAN, Retina and anterior neural fold homeobox protein 2, Retina and anterior neural fold homeobox-like protein 1
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q96IS3
Length: 184
Pfam Domains: 28-84 Homeobox domain
Sequence:
(in bold interface residues)
1 MFLSPGEGPATEGGGLGPGEEAPKKKHRRNRTTFTTYQLHQLERAFEASHYPDVYSREEL 60
61 AAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAVAAPRLPEAPALPFARPPAMSLPLEP 120
121 WLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASLRLLAKEHAQALDRA 180
181 WPPA
Interface Residues: 28, 29, 30, 31, 69, 70, 72, 73, 76, 77, 80, 81, 84
3D-footprint Homologues: 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 2h1k_B, 2lkx_A, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2ld5_A, 2hdd_A, 7q3o_C, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 6m3d_C, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 5hod_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 4qtr_D, 1o4x_A, 8g87_X, 1du0_A
Binding Motifs: MA0717.1 yyAATTAr
MA0717.2 yAATTA
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.