Transcription Factor
| Accessions: | Q8TE12 (JASPAR 2024) |
| Names: | LIM homeobox transcription factor 1-alpha, LIM/homeobox protein 1.1, LIM/homeobox protein LMX1A, LMX-1.1, LMX1A_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 382 |
| Pfam Domains: | 35-90 LIM domain 94-151 LIM domain 196-252 Homeobox domain 220-248 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MLDGLKMEENFQSAIDTSASFSSLLGRAVSPKSVCEGCQRVILDRFLLRLNDSFWHEQCV 60 61 QCASCKEPLETTCFYRDKKLYCKYDYEKLFAVKCGGCFEAIAPNEFVMRAQKSVYHLSCF 120 121 CCCVCERQLQKGDEFVLKEGQLLCKGDYEKERELLSLVSPAASDSGKSDDEESLCKSAHG 180 181 AGKGTAEEGKDHKRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQ 240 241 VWFQNQRAKMKKLARRQQQQQQDQQNTQRLSSAQTNGGGSAGMEGIMNPYTALPTPQQLL 300 301 AIEQSVYSSDPFRQGLTPPQMPGDHMHPYGAEPLFHDLDSDDTSLSNLGDCFLATSEAGP 360 361 LQSRVGNPIDHLYSMQNSYFTS |
| Interface Residues: | 195, 196, 197, 198, 199, 237, 238, 240, 241, 244, 245, 248, 249, 252 |
| 3D-footprint Homologues: | 3d1n_M, 5zfz_A, 1ig7_A, 6a8r_A, 3cmy_A, 2h1k_B, 1fjl_B, 1nk2_P, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 1puf_A, 2lkx_A, 2ld5_A, 1b72_A, 4cyc_A, 2r5y_A, 5flv_I, 3l1p_A, 2hos_A, 3a01_E, 2d5v_B, 7psx_B, 5hod_A, 7q3o_C, 1au7_A, 5jlw_D, 3rkq_B, 6es3_K, 4xrs_G, 2hdd_A, 1e3o_C, 1le8_A, 7xrc_C, 1o4x_A, 8g87_X, 1du0_A, 5zjt_E, 4qtr_D, 4xrm_B, 1puf_B |
| Binding Motifs: | MA0702.1 tTAATTAa MA0702.2 yTAATTAm MA0702.3 yTAATTA |
| Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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