Transcription Factor

						

			
Accessions: 3dnv_B (3D-footprint 20231221), 4yg4_B (3D-footprint 20231221), 4yg7_C (3D-footprint 20231221), 4yg7_G (3D-footprint 20231221), 4z58_A (3D-footprint 20231221), 4z59_A (3D-footprint 20231221), 4z5c_A (3D-footprint 20231221), 4z5c_B (3D-footprint 20231221), 4z5d_A (3D-footprint 20231221), 4z5d_B (3D-footprint 20231221)

			
Names: HIPB_ECOLI, HTH-type transcriptional regulator hipB, Antitoxin HipB
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P23873
Length: 71
Pfam Domains:      9-64 Helix-turn-helix domain
     9-62 Helix-turn-helix domain
    13-64 Helix-turn-helix domain
    15-66 Helix-turn-helix
    19-64 Cro/C1-type HTH DNA-binding domain
Sequence: 
(in bold interface residues)		   1 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQS   60
  61 LELSMTLCDAK
Interface Residues: 25, 26, 35, 36, 37, 38, 40, 41, 44, 47, 48
3D-footprint Homologues: 3cro_R, 3oqm_C, 1per_L, 5k98_B, 3dnv_B, 4z5h_A, 3zkc_A, 4lln_I, 5gpc_B
Binding Motifs: 3dnv_AB / 3dnv_B TATc
4z58_A TATc
4z59_A TATc
4z5d_B tAtCC
4yg4_ABCD ATaCnnnnnnngGGA
4yg4_B TCCC
4yg7_BCDEGK TAnCCnnnnngGATAnnnnnnnnnnTAnnCCnnnnnGGGAT
4z5c_AB TATCCCnnnnnnCGGATA
4z5c_B TATCCC
4z5d_AB TAtCCrnnnnnnnGGwTA
Binding Sites: 3dnv_T
4yg4_F
4yg4_T
4yg7_R
4yg7_T
4z58_B
4z59_B
4z5c_C
4z5c_D
4z5d_C
4z5d_D
			
Publications: Schumacher M.A, Piro K.M, Xu W, Hansen S, Lewis K, Brennan R.G. Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science (New York, N.Y.) 323:396-401 (2009). [Pubmed]


Schumacher MA, Balani P, Min J, Chinnam NB, Hansen S, Vulić M, Lewis K, Brennan RG. HipBA-promoter structures reveal the basis of heritable multidrug tolerance. Nature 524:59-64 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.