Transcription Factor

Accessions: T133242_1.02 (CISBP 1.02), NR5A2_MOUSE (HOCOMOCO 10), P45448 (JASPAR 2024)
Names: Nr5a2, T133242_1.02;, Liver receptor homolog 1, LRH-1, NR5A2_MOUSE, Nuclear receptor subfamily 5 group A member 2
Organisms: Mus musculus
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:Nuclear receptor
Length: 560
Pfam Domains: 106-173 Zinc finger, C4 type (two domains)
345-535 Ligand-binding domain of nuclear hormone receptor
Sequence:
(in bold interface residues)
1 MSASLDTGDFQEFLKHGLTAIASAPGSETRHSPKREEQLREKRAGLPDRHRRPIPARSRL 60
61 VMLPKVETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYG 120
121 LLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRAD 180
181 RMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAIQNIHSASK 240
241 GLPLSHVALPPTDYDRSPFVTSPISMTMPPHSSLHGYQPYGHFPSRAIKSEYPDPYSSSP 300
301 ESMMGYSYMDGYQTNSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQSNRNRQEKLSA 360
361 FGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEG 420
421 TIFLVTGEHVDYSTIISHTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDV 480
481 KNLENLQLVEGVQEQVNAALLDYTVCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKH 540
541 VNGDVPYNNLLIEMLHAKRA
Interface Residues: 104, 113, 115, 116, 117, 118, 119, 125, 126, 128, 129, 132, 133, 157, 179, 181, 183, 186, 188
3D-footprint Homologues: 8dwj_A, 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 8hbm_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B
Binding Motifs: MA0505.1 ragtTCAAGGyCAgs
M1448_1.02 YGACCTTg
NR5A2_MOUSE.H10MO.A|M01266 yyCAAGGyCAs
MA0505.2 vTGaCCTTGAmct
MA0505.3 TGaCCTTGA
Binding Sites: MA0505.3.16 / MA0505.3.2 / MA0505.3.6
MA0505.1.1
MA0505.1.10
MA0505.1.11
MA0505.1.12
MA0505.1.13
MA0505.1.14
MA0505.1.15
MA0505.1.16
MA0505.1.17
MA0505.1.18 / MA0505.1.19
MA0505.1.2
MA0505.1.20
MA0505.1.3
MA0505.1.4
MA0505.1.5
MA0505.1.6
MA0505.1.7
MA0505.1.8
MA0505.1.9
MA0505.3.1
MA0505.2.1 / MA0505.2.4
MA0505.2.10 / MA0505.2.17
MA0505.2.11 / MA0505.2.20
MA0505.2.12
MA0505.2.13
MA0505.2.14
MA0505.2.15
MA0505.2.16
MA0505.2.17
MA0505.2.18
MA0505.2.19
MA0505.2.2 / MA0505.2.5
MA0505.2.20
MA0505.2.3 / MA0505.2.6
MA0505.2.4 / MA0505.2.7
MA0505.2.5 / MA0505.2.8
MA0505.2.6 / MA0505.2.9
MA0505.2.11 / MA0505.2.7
MA0505.2.8
MA0505.2.16 / MA0505.2.9
MA0505.2.1
MA0505.2.10
MA0505.2.12
MA0505.2.13
MA0505.2.14
MA0505.2.15
MA0505.2.18
MA0505.2.19
MA0505.2.2
MA0505.2.3
MA0505.3.10 / MA0505.3.15
MA0505.3.11
MA0505.3.12
MA0505.3.13 / MA0505.3.17 / MA0505.3.20
MA0505.3.14
MA0505.3.18
MA0505.3.19
MA0505.3.3
MA0505.3.4
MA0505.3.5
MA0505.3.7
MA0505.3.8
MA0505.3.9
Publications: Fayard E., Schoonjans K., Annicotte J. S., Auwerx J. Liver receptor homolog 1 controls the expression of carboxyl ester lipase.. J. Biol. Chem. 278:35725-35731 (2003). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.