Transcription Factor
Accessions: | T133242_1.02 (CISBP 1.02), NR5A2_MOUSE (HOCOMOCO 10), P45448 (JASPAR 2024) |
Names: | Nr5a2, T133242_1.02;, Liver receptor homolog 1, LRH-1, NR5A2_MOUSE, Nuclear receptor subfamily 5 group A member 2 |
Organisms: | Mus musculus |
Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Notes: | experiment type:PBM, family:Nuclear receptor |
Length: | 560 |
Pfam Domains: | 106-173 Zinc finger, C4 type (two domains) 345-535 Ligand-binding domain of nuclear hormone receptor |
Sequence: (in bold interface residues) | 1 MSASLDTGDFQEFLKHGLTAIASAPGSETRHSPKREEQLREKRAGLPDRHRRPIPARSRL 60 61 VMLPKVETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYG 120 121 LLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRAD 180 181 RMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAIQNIHSASK 240 241 GLPLSHVALPPTDYDRSPFVTSPISMTMPPHSSLHGYQPYGHFPSRAIKSEYPDPYSSSP 300 301 ESMMGYSYMDGYQTNSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQSNRNRQEKLSA 360 361 FGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEG 420 421 TIFLVTGEHVDYSTIISHTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDV 480 481 KNLENLQLVEGVQEQVNAALLDYTVCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKH 540 541 VNGDVPYNNLLIEMLHAKRA |
Interface Residues: | 104, 113, 115, 116, 117, 118, 119, 125, 126, 128, 129, 132, 133, 157, 179, 181, 183, 186, 188 |
3D-footprint Homologues: | 8dwj_A, 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 8hbm_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B |
Binding Motifs: | MA0505.1 ragtTCAAGGyCAgs M1448_1.02 YGACCTTg NR5A2_MOUSE.H10MO.A|M01266 yyCAAGGyCAs MA0505.2 vTGaCCTTGAmct MA0505.3 TGaCCTTGA |
Binding Sites: | MA0505.3.16 / MA0505.3.2 / MA0505.3.6 MA0505.1.1 MA0505.1.10 MA0505.1.11 MA0505.1.12 MA0505.1.13 MA0505.1.14 MA0505.1.15 MA0505.1.16 MA0505.1.17 MA0505.1.18 / MA0505.1.19 MA0505.1.2 MA0505.1.20 MA0505.1.3 MA0505.1.4 MA0505.1.5 MA0505.1.6 MA0505.1.7 MA0505.1.8 MA0505.1.9 MA0505.3.1 MA0505.2.1 / MA0505.2.4 MA0505.2.10 / MA0505.2.17 MA0505.2.11 / MA0505.2.20 MA0505.2.12 MA0505.2.13 MA0505.2.14 MA0505.2.15 MA0505.2.16 MA0505.2.17 MA0505.2.18 MA0505.2.19 MA0505.2.2 / MA0505.2.5 MA0505.2.20 MA0505.2.3 / MA0505.2.6 MA0505.2.4 / MA0505.2.7 MA0505.2.5 / MA0505.2.8 MA0505.2.6 / MA0505.2.9 MA0505.2.11 / MA0505.2.7 MA0505.2.8 MA0505.2.16 / MA0505.2.9 MA0505.2.1 MA0505.2.10 MA0505.2.12 MA0505.2.13 MA0505.2.14 MA0505.2.15 MA0505.2.18 MA0505.2.19 MA0505.2.2 MA0505.2.3 MA0505.3.10 / MA0505.3.15 MA0505.3.11 MA0505.3.12 MA0505.3.13 / MA0505.3.17 / MA0505.3.20 MA0505.3.14 MA0505.3.18 MA0505.3.19 MA0505.3.3 MA0505.3.4 MA0505.3.5 MA0505.3.7 MA0505.3.8 MA0505.3.9 |
Publications: | Fayard E., Schoonjans K., Annicotte J. S., Auwerx J. Liver receptor homolog 1 controls the expression of carboxyl ester lipase.. J. Biol. Chem. 278:35725-35731 (2003). [Pubmed] |
Related annotations: | PaperBLAST |
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