Transcription Factor
| Accessions: | UP00460A (UniPROBE 20160601), P54785 (JASPAR 2024) |
| Names: | Modifier of Transcription, Mot3, ROX7, Hypoxic gene repressor protein 7, Modulator of transcription protein 3, MOT3_YEAST, Transcriptional activator/repressor MOT3 |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Modifier of Transcription : Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcr |
| Length: | 490 |
| Pfam Domains: | 346-368 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MNADHHLQQQQQQRQQHQQQQHQQQQHQHQHQQQQHTILQNVSNTNNIGSDSLASQPFNT 60 61 TTVSSNKDDVMVNSGARELPMPLHQQQYIYPYYQYTSNNSNNNNVTAGNNMSASPIVHNN 120 121 SNNSNNSNISASDYTVANNSTSNNNNNNNNNNNNNNNIHPNQFTAAANMNSNAAAAAYYS 180 181 FPTANMPIPQQDQQYMFNPASYISHYYSAVNSNNNGNNAANNGSNNSSHSAPAPAPGPPH 240 241 HHHHHSNTHNNLNNGGAVNTNNAPQHHPTIITDQFQFQLQQNPSPNLNLNINPAQPLHLP 300 301 PGWKINTMPQPRPTTAPNHPPAPVPSSNPVASNLVPAPSSDHKYIHQCQFCEKSFKRKSW 360 361 LKRHLLSHSQQRHFLCPWCLSRQKRKDNLLQHMKLKHTNYLLDELKKNNIIFNYNNSSSS 420 421 NNNNDNNNNNNSNSASGSGGAGAAAAAATAPENEDGNGYDTNIKTLINDGVLNKDDVKRV 480 481 LNNLIVSHNK |
| Interface Residues: | 325, 326, 328, 331, 332, 333, 342, 356, 357, 358, 359, 360, 362, 363, 364, 383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 395, 396 |
| 3D-footprint Homologues: | 8ssq_A, 7w1m_H, 8ssu_A, 5yel_A, 6jnm_A, 3uk3_C, 8cuc_F, 7y3l_A, 7n5w_A, 1g2f_F, 2jpa_A, 1llm_D, 5und_A, 2drp_D, 5k5i_A, 2kmk_A, 1mey_C, 6ml4_A, 5v3j_F, 2gli_A, 8gn3_A, 1f2i_J, 6blw_A, 5kkq_D, 2lt7_A, 6u9q_A, 4x9j_A, 2i13_A, 7txc_E, 5kl3_A, 1ubd_C, 7ysf_A, 6wmi_A, 5ei9_F, 7eyi_G, 4m9v_C, 8h9h_G, 1tf3_A, 7y3m_I, 6e94_A, 6a57_A, 2wbs_A, 5yj3_D |
| Binding Motifs: | UP00460A_1 / UP00460A_2 crctskarmAGGCACskysgay UP00460A_3 wTTACAyr MA0340.1 hAGGyA |
| Binding Sites: | AAAGGCAC AAGGCACA AAGGCACC AAGGCACG ACAGGCAC ACGTGCCT AGGCACCA AGGCACCC AGGCACGC ATAGGCAC CAGGCACA CAGGCACC CAGGCACG CGTGCCTA GAAGGCAC GCAGGCAA GCAGGCAC GGTGCCTA GTAGGCAC GTGCCTGA |
| Publications: | Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed] MacIsaac K.D, Wang T, Gordon D.B, Gifford D.K, Stormo G.D, Fraenkel E. An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC bioinformatics 7:113 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
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