Transcription Factor
| Accessions: | cad (DrosophilaTF 1.1), P09085 (JASPAR 2024) |
| Names: | CAD_DROME |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P09085 |
| Length: | 427 |
| Pfam Domains: | 275-330 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MVSHYYNTLPYTQKHSAANLAYASAAGQPWNWTPNYHHTPPNHQFLGDVDSSHAAHHAAA 60 61 AHQMYYNSHHMFHSAAAASAGEWHSPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSS 120 121 ASSGSSSSGGAPGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPS 180 181 PPITVSGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVS 240 241 NNNRTSPSKPPYFDWMKKPAYPAQPQPGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITI 300 301 RRKSELAQTLSLSERQVKIWFQNRRAKERKQNKKGSDPNVMGVGVQHADYSQLLDAKAKL 360 361 EPGLHLSHSLAHSMNPMAAMNIPAMRLHPHLAAHSHSLAAVAAHSHQLQQQHSAQMSAAA 420 421 AVGTLSM |
| Interface Residues: | 266, 267, 269, 270, 271, 274, 275, 276, 277, 280, 315, 316, 318, 319, 322, 323, 326, 327, 329, 330 |
| 3D-footprint Homologues: | 3a01_E, 1mnm_C, 1le8_B, 1k61_B, 1puf_A, 1zq3_P, 2lkx_A, 1jgg_B, 3lnq_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 5zfz_A, 3rkq_B, 1ig7_A, 6m3d_C, 5flv_I, 2h1k_B, 5zjt_E, 4cyc_A, 7psx_B, 5hod_A, 3cmy_A, 2hdd_A, 6a8r_A, 2r5y_A, 5jlw_D, 2hos_A, 1fjl_B, 4xrs_G, 1b72_A, 1le8_A, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D, 1puf_B |
| Binding Motifs: | MA0216.1 TTTATTr cad TTTATG MA0216.2 rgymATAAAAm |
| Binding Sites: | MA0216.1.12 MA0216.1.1 MA0216.1.10 MA0216.1.11 MA0216.1.13 MA0216.1.14 MA0216.1.15 MA0216.1.16 MA0216.1.17 MA0216.1.18 MA0216.1.19 MA0216.1.2 MA0216.1.20 MA0216.1.3 MA0216.1.4 MA0216.1.5 MA0216.1.6 MA0216.1.7 MA0216.1.8 MA0216.1.9 MA0216.2.1 MA0216.2.10 MA0216.2.11 MA0216.2.12 MA0216.2.13 MA0216.2.14 MA0216.2.15 MA0216.2.16 MA0216.2.17 MA0216.2.18 MA0216.2.19 MA0216.2.2 MA0216.2.20 MA0216.2.3 MA0216.2.4 MA0216.2.5 MA0216.2.6 MA0216.2.7 MA0216.2.8 MA0216.2.9 |
| Publications: | Dearolf C. R., Topol J., Parker C. S. The caudal gene product is a direct activator of fushi tarazu transcription during Drosophila embryogenesis. Nature 341:340 (1989). [Pubmed] Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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