Transcription Factor
| Accessions: | 1zgw_A (3D-footprint 20231221) |
| Names: | Ada polyprotein, ADA_ECOLI, Bifunctional transcriptional activator/DNA repair enzyme Ada, EC 2.1.1.63, EC 2.1.1.n11, Methylphosphotriester-DNA methyltransferase, O6-methylguanine-DNA alkyltransferase, Regulatory protein of adaptive response |
| Organisms: | Escherichia coli, strain K12 |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P06134 |
| Length: | 138 |
| Pfam Domains: | 10-74 Metal binding domain of Ada 97-132 Bacterial regulatory helix-turn-helix proteins, AraC family 104-137 Helix-turn-helix domain |
| Sequence: (in bold interface residues) | 1 MKKATCLTDDQRWQSVLARDPNADGEFVFAVRTTGIFRPSCRARHALRENVSFYANASEA 60 61 LAAGFRPCKRCQPDKANPRQHRLDKITHACRLLEQETPVTLEALADQVAMSPFHLHRLFK 120 121 ATTGMTPKAWQQAWRARR |
| Interface Residues: | 34, 43, 44, 70, 111, 113, 114, 116, 117, 120, 128 |
| 3D-footprint Homologues: | 1zgw_A, 7vwz_G, 1xs9_A |
| Binding Motifs: | 1zgw_A tTGCGnntTAAT |
| Binding Sites: | 1zgw_B 1zgw_C |
| Publications: | He C, Hus J.C, Sun L.J, Zhou P, Norman D.P, Dötsch V, Wei H, Gross J.D, Lane W.S, Wagner G, Verdine G.L. A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. Molecular cell 20:117-29 (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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