Transcription Factor
| Accessions: | T137961_1.02 (CISBP 1.02), UP00321A (UniPROBE 20160601), UP00398A (UniPROBE 20160601), P11938 (JASPAR 2024) |
| Names: | RAP1, T137961_1.02;, "DNA-binding protein RAP1, GRF1, N1310, Repressor/activator site-binding protein, SBF-E, TBA1, TUF, TUF1, YNL216W", DNA-binding protein RAP1, RAP1_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | "DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (sil..." |
| Notes: | experiment type:PBM, family:Rap1 |
| Length: | 827 |
| Pfam Domains: | 362-411 Myb-like DNA-binding domain 448-579 Rap1, DNA-binding 721-821 Rap1 - C terminal domain |
| Sequence: (in bold interface residues) | 1 MSSPDDFETAPAEYVDALDPSMVVVDSGSAAVTAPSDSAAEVKANQNEENTGATAAETSE 60 61 KVDQTEVEKKDDDDTTEVGVTTTTPSIADTAATANIASTSGASVTEPTTDDTAADEKKEQ 120 121 VSGPPLSNMKFYLNRDADAHDSLNDIDQLARLIRANGGEVLDSKPRESKENVFIVSPYNH 180 181 TNLPTVTPTYIKACCQSNSLLNMENYLVPYDNFREVVDSRLQEESHSNGVDNSNSNSDNK 240 241 DSIRPKTEIISTNTNGATEDSTSEKVMVDAEQQARLQEQAQLLRQHVSSTASITSGGHND 300 301 LVQIEQPQKDTSNNNNSNVNDEDNDLLTQDNNPQTADEGNASFQAQRSMISRGALPSHNK 360 361 ASFTDEEDEFILDVVRKNPTRRTTHTLYDEISHYVPNHTGNSIRHRFRVYLSKRLEYVYE 420 421 VDKFGKLVRDDDGNLIKTKVLPPSIKRKFSADEDYTLAIAVKKQFYRDLFQIDPDTGRSL 480 481 ITDEDTPTAIARRNMTMDPNHVPGSEPNFAAYRTQSRRGPIAREFFKHFAEEHAAHTENA 540 541 WRDRFRKFLLAYGIDDYISYYEAEKAQNREPEPMKNLTNRPKRPGVPTPGNYNSAAKRAR 600 601 NYSSQRNVQPTANAASANAAAAAAAAASNSYAIPENELLDEDTMNFISSLKNDLSNISNS 660 661 LPFEYPHEIAEAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKL 720 721 HEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPP 780 781 PNVPGIWTHDDDESLKSNDQEQIRKLVKKHGTGRMEMRKRFFEKDLL |
| Interface Residues: | 360, 385, 400, 401, 402, 404, 405, 408, 409, 410, 446, 539, 542, 543, 546, 547, 578, 588, 589, 591 |
| 3D-footprint Homologues: | 1ign_A, 3zqc_A, 6kks_A |
| Binding Motifs: | UP00321A_1 rkgtyrkGGTGTACgGrtat UP00398A_1 yktwcrCCCgtACACCCcrdaam M1515_1.02 GGGTGYAC MA0359.1 CACCCRtACA MA0359.2 drTGTaTGGGTGTww MA0359.3 rTGTaTGGGTGT |
| Binding Sites: | AACACCCA ACACCCAA ACACCCAC ACACCCAG ACACCCAT ACACCCCC ACCCATAC AGAGGGGG AGGGGGAG AGGGTGTA AGTACACC CCCGTGCA CGTACACC CGTGCACC CTTCCCCC GAGGGGGA GGATGTAC GGGGTGTA GGGTGCAC GGGTGTAC GGTACACC GGTGCACC GGTGTACA GTACACCA GTGCACCA TACACCCA TGCACCCA AGGGGGTA CATCCCCC GAACACCC MA0359.2.1 / MA0359.2.2 MA0359.2.10 / MA0359.2.14 MA0359.2.11 / MA0359.2.15 MA0359.2.12 / MA0359.2.16 MA0359.2.13 / MA0359.2.19 / MA0359.2.20 MA0359.2.14 / MA0359.2.17 MA0359.2.15 / MA0359.2.18 MA0359.2.16 / MA0359.2.19 MA0359.2.2 / MA0359.2.3 MA0359.2.3 / MA0359.2.4 MA0359.2.4 / MA0359.2.5 MA0359.2.5 / MA0359.2.7 MA0359.2.6 / MA0359.2.8 MA0359.2.10 / MA0359.2.13 / MA0359.2.7 / MA0359.2.9 MA0359.2.11 / MA0359.2.8 MA0359.2.1 MA0359.2.12 / MA0359.2.9 MA0359.2.17 MA0359.2.18 MA0359.2.20 MA0359.2.6 MA0359.3.1 MA0359.3.10 MA0359.3.11 MA0359.3.12 / MA0359.3.8 MA0359.3.13 / MA0359.3.20 MA0359.3.14 / MA0359.3.17 MA0359.3.15 / MA0359.3.18 MA0359.3.16 / MA0359.3.19 MA0359.3.2 MA0359.3.3 MA0359.3.4 MA0359.3.5 MA0359.3.6 MA0359.3.7 / MA0359.3.9 |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Berger M.F, Philippakis A.A, Qureshi A.M, He F.S, Estep P.W, Bulyk M.L. Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nature biotechnology 24:1429-35 (2006). [Pubmed] Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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