Transcription Factor
| Accessions: | T015228_1.02 (CISBP 1.02), P70660 (JASPAR 2024) |
| Names: | Neurog1, T015228_1.02;, Helix-loop-helix protein mATH-4C, mATH4C, NeuroD3, Neurogenic basic-helix-loop-helix protein, Neurogenic differentiation factor 3, Neurogenin-1, NGN-1, NGN1_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:bHLH |
| Length: | 244 |
| Pfam Domains: | 94-145 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MPAPLETCISDLDCSSSNSSSDLSSFLTDEEDCARLQPLASTSGLSVPARRSAPALSGAS 60 61 NVPGAQDEEQERRRRRGRARVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVL 120 121 PSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGSARERLLPPQCVPCLPGPPSP 180 181 ASDTESWGSGAAASPCATVASPLSDPSSPSASEDFTYGPGDPLFSFPGLPKDLLHTTPCF 240 241 IPYH |
| Interface Residues: | 95, 98, 99, 101, 102, 103, 105, 106, 115, 118, 119, 121, 122, 131 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 6od3_F, 4h10_B, 7ssa_L, 2ypa_B, 2ql2_D, 5gnj_I, 4iri_A |
| Binding Motifs: | M0217_1.02 acMaTATGky MA0623.1 acMaTATGky |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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