Transcription Factor
| Accessions: | ESRRB_DBD (HumanTF 1.0), ESRRB_TF1 (HumanTF2 1.0), ESRRB_TF2 (HumanTF2 1.0), ESRRB (HT-SELEX2 May2017) |
| Names: | ERR beta-2, ERR-beta, ERR2_HUMAN, ESRRB, Estrogen receptor-like 2, Estrogen-related receptor beta, Nuclear receptor subfamily 3 group B member 2, Steroid hormone receptor ERR2, ENSG00000119715 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O95718 |
| Notes: | Ensembl ID: ENSG00000119715; DNA-binding domain sequence; TF family: Nuclear_Receptor; Clone source: Gene synthesis, Ensembl ID: ENSG00000119715; Construct type: TF1(SBP); TF family: Nuclear_receptor; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000119715; Construct type: TF2(3xFLAG); TF family: Nuclear_receptor; Clone source: Jolma et al. 2013, TF family: Nuclear_receptor experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Nuclear_receptor experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 109 |
| Pfam Domains: | 18-86 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 EDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNE 60 61 CEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSES |
| Interface Residues: | 27, 28, 30, 31, 37, 38, 40, 41, 44, 45, 69, 91, 93, 95, 98 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A |
| Binding Motifs: | ESRRB_DBD TCAAGGTCAww HOXB2_ESRRB_1 TAATkrcsatbtCAAGGTCA HOXB2_ESRRB_2 TAATkrcswbyCAAGGTCA TEAD4_ESRRB_1 rcATwcywkddcAAGGTCAw TEAD4_ESRRB_2 rcATwcckstcAAGGTCA ESRRB_2 btSAAGGTCry ESRRB_methyl_1 btsAAGGTCRh |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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