Transcription Factor

Accessions: ARNTL (HT-SELEX2 May2017)
Names: ARNTL, ENSG00000133794
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2
Length: 126
Pfam Domains: 29-80 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 YQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAM 60
61 SRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCD 120
121 RGKILF
Interface Residues: 29, 31, 32, 33, 35, 36, 39, 40, 42, 43, 44, 46, 62, 63, 64, 65, 66, 69
3D-footprint Homologues: 7z5k_B, 1a0a_B, 1an4_A, 8osl_O, 7f2f_B, 1am9_A, 7ssa_L, 5nj8_D, 4h10_A, 7xq5_A, 6g1l_A, 4h10_B, 7d8t_A, 5gnj_I, 7xi3_A, 5v0l_A, 4zpk_A, 8osl_P, 5nj8_C, 7xhv_B, 2ypa_A, 3hqg_A, 4zpk_B, 4zpr_B, 5sy7_B, 7xi3_B, 5v0l_B
Binding Motifs: ARNTL_2 rtCACGTGms
ARNTL_methyl_1 rtCAyGTGms
Related annotations: PaperBLAST

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